Tumor DNA From Tumor In Situ Fluid Reveals Mutation Landscape of Minimal Residual Disease After Glioma Surgery and Risk of Early Recurrence

The recurrence of glioma is a difficult problem in clinical treatment. The molecular markers of primary tumors after resection cannot fully represent the characteristics of recurrent tumors. Here, abundant tumor DNA was detected in tumor in situ fluid (TISF). We report that TISF-derived tumor DNA (T...

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Autores principales: Yu, Jinliang, Sheng, Zhiyuan, Wu, Shuang, Gao, Yushuai, Yan, Zhaoyue, Bu, Chaojie, Gu, Jianjun, Bu, Yage, Deng, Kaiyuan, Xu, Sensen, Chen, Zhongcan, Zhang, Qianqian, Zemmar, Ajmal, Hernesniemi, Juha, Wang, Meiyun, Liu, Gang, Li, Tianxiao, Bu, Xingyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547270/
https://www.ncbi.nlm.nih.gov/pubmed/34712610
http://dx.doi.org/10.3389/fonc.2021.742037
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author Yu, Jinliang
Sheng, Zhiyuan
Wu, Shuang
Gao, Yushuai
Yan, Zhaoyue
Bu, Chaojie
Gu, Jianjun
Bu, Yage
Deng, Kaiyuan
Xu, Sensen
Chen, Zhongcan
Zhang, Qianqian
Zemmar, Ajmal
Hernesniemi, Juha
Wang, Meiyun
Liu, Gang
Li, Tianxiao
Bu, Xingyao
author_facet Yu, Jinliang
Sheng, Zhiyuan
Wu, Shuang
Gao, Yushuai
Yan, Zhaoyue
Bu, Chaojie
Gu, Jianjun
Bu, Yage
Deng, Kaiyuan
Xu, Sensen
Chen, Zhongcan
Zhang, Qianqian
Zemmar, Ajmal
Hernesniemi, Juha
Wang, Meiyun
Liu, Gang
Li, Tianxiao
Bu, Xingyao
author_sort Yu, Jinliang
collection PubMed
description The recurrence of glioma is a difficult problem in clinical treatment. The molecular markers of primary tumors after resection cannot fully represent the characteristics of recurrent tumors. Here, abundant tumor DNA was detected in tumor in situ fluid (TISF). We report that TISF-derived tumor DNA (TISF-DNA) can detect genomic changes in recurrent tumors and facilitate recurrence risk analysis, providing valuable information for diagnosis and prognosis. The tumor DNA in TISF is more representative and sensitive than that in cerebrospinal fluid. It reveals the mutational landscape of minimal residual disease after glioma surgery and the risk of early recurrence, contributing to the clinical management and clinical research of glioma patients.
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spelling pubmed-85472702021-10-27 Tumor DNA From Tumor In Situ Fluid Reveals Mutation Landscape of Minimal Residual Disease After Glioma Surgery and Risk of Early Recurrence Yu, Jinliang Sheng, Zhiyuan Wu, Shuang Gao, Yushuai Yan, Zhaoyue Bu, Chaojie Gu, Jianjun Bu, Yage Deng, Kaiyuan Xu, Sensen Chen, Zhongcan Zhang, Qianqian Zemmar, Ajmal Hernesniemi, Juha Wang, Meiyun Liu, Gang Li, Tianxiao Bu, Xingyao Front Oncol Oncology The recurrence of glioma is a difficult problem in clinical treatment. The molecular markers of primary tumors after resection cannot fully represent the characteristics of recurrent tumors. Here, abundant tumor DNA was detected in tumor in situ fluid (TISF). We report that TISF-derived tumor DNA (TISF-DNA) can detect genomic changes in recurrent tumors and facilitate recurrence risk analysis, providing valuable information for diagnosis and prognosis. The tumor DNA in TISF is more representative and sensitive than that in cerebrospinal fluid. It reveals the mutational landscape of minimal residual disease after glioma surgery and the risk of early recurrence, contributing to the clinical management and clinical research of glioma patients. Frontiers Media S.A. 2021-10-11 /pmc/articles/PMC8547270/ /pubmed/34712610 http://dx.doi.org/10.3389/fonc.2021.742037 Text en Copyright © 2021 Yu, Sheng, Wu, Gao, Yan, Bu, Gu, Bu, Deng, Xu, Chen, Zhang, Zemmar, Hernesniemi, Wang, Liu, Li and Bu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yu, Jinliang
Sheng, Zhiyuan
Wu, Shuang
Gao, Yushuai
Yan, Zhaoyue
Bu, Chaojie
Gu, Jianjun
Bu, Yage
Deng, Kaiyuan
Xu, Sensen
Chen, Zhongcan
Zhang, Qianqian
Zemmar, Ajmal
Hernesniemi, Juha
Wang, Meiyun
Liu, Gang
Li, Tianxiao
Bu, Xingyao
Tumor DNA From Tumor In Situ Fluid Reveals Mutation Landscape of Minimal Residual Disease After Glioma Surgery and Risk of Early Recurrence
title Tumor DNA From Tumor In Situ Fluid Reveals Mutation Landscape of Minimal Residual Disease After Glioma Surgery and Risk of Early Recurrence
title_full Tumor DNA From Tumor In Situ Fluid Reveals Mutation Landscape of Minimal Residual Disease After Glioma Surgery and Risk of Early Recurrence
title_fullStr Tumor DNA From Tumor In Situ Fluid Reveals Mutation Landscape of Minimal Residual Disease After Glioma Surgery and Risk of Early Recurrence
title_full_unstemmed Tumor DNA From Tumor In Situ Fluid Reveals Mutation Landscape of Minimal Residual Disease After Glioma Surgery and Risk of Early Recurrence
title_short Tumor DNA From Tumor In Situ Fluid Reveals Mutation Landscape of Minimal Residual Disease After Glioma Surgery and Risk of Early Recurrence
title_sort tumor dna from tumor in situ fluid reveals mutation landscape of minimal residual disease after glioma surgery and risk of early recurrence
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547270/
https://www.ncbi.nlm.nih.gov/pubmed/34712610
http://dx.doi.org/10.3389/fonc.2021.742037
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