Cargando…

Novel Drivers of Virulence in Clostridioides difficile Identified via Context-Specific Metabolic Network Analysis

The pathogen Clostridioides difficile causes toxin-mediated diarrhea and is the leading cause of hospital-acquired infection in the United States. Due to growing antibiotic resistance and recurrent infection, targeting C. difficile metabolism presents a new approach to combat this infection. Genome-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jenior, Matthew L., Leslie, Jhansi L., Powers, Deborah A., Garrett, Elizabeth M., Walker, Kimberly A., Dickenson, Mary E., Petri, William A., Tamayo, Rita, Papin, Jason A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547418/ https://www.ncbi.nlm.nih.gov/pubmed/34609164 http://dx.doi.org/10.1128/mSystems.00919-21

Ejemplares similares

Network analysis of toxin production in Clostridioides difficile identifies key metabolic dependencies
por: Powers, Deborah A., et al.
Publicado: (2023)

Clostridioides difficile Binary Toxin Binding Component Increases Virulence in a Hamster Model
por: Simpson, Morgan, et al.
Publicado: (2023)

Protection from Lethal Clostridioides difficile Infection via Intraspecies Competition for Cogerminant
por: Leslie, Jhansi L., et al.
Publicado: (2021)

The Gut Microbiota Is Associated with Clearance of Clostridium difficile Infection Independent of Adaptive Immunity
por: Leslie, Jhansi L., et al.
Publicado: (2019)

Binary Toxin Expression by Clostridioides difficile Is Associated With Worse Disease
por: Young, Mary K, et al.
Publicado: (2022)

Pathogenicity and virulence of Clostridioides difficile
por: Buddle, Jessica E., et al.
Publicado: (2023)

Genome-scale metabolic modeling reveals increased reliance on valine catabolism in clinical isolates of Klebsiella pneumoniae
por: Jenior, Matthew L., et al.
Publicado: (2022)

Rho factor mediates flagellum and toxin phase variation and impacts virulence in Clostridioides difficile
por: Trzilova, Dominika, et al.
Publicado: (2020)

Clostridium difficile Colonizes Alternative Nutrient Niches during Infection across Distinct Murine Gut Microbiomes
por: Jenior, Matthew L., et al.
Publicado: (2017)

The Gut Bacterial Community Potentiates Clostridioides difficile Infection Severity
por: Lesniak, Nicholas A., et al.
Publicado: (2022)

Phase variation of a signal transduction system controls Clostridioides difficile colony morphology, motility, and virulence
por: Garrett, Elizabeth M., et al.
Publicado: (2019)

Clostridium difficile Alters the Structure and Metabolism of Distinct Cecal Microbiomes during Initial Infection To Promote Sustained Colonization
por: Jenior, Matthew L., et al.
Publicado: (2018)

Dogs as carriers of virulent and resistant genotypes of Clostridioides difficile
por: Finsterwalder, SK, et al.
Publicado: (2022)

Multiple Regulatory Mechanisms Control the Production of CmrRST, an Atypical Signal Transduction System in Clostridioides difficile
por: Garrett, Elizabeth M., et al.
Publicado: (2022)

c-di-GMP Inhibits Early Sporulation in Clostridioides difficile
por: Edwards, Adrianne N., et al.
Publicado: (2021)

Characterizing metabolic drivers of Clostridioides difficile infection with activity-based hydrazine probes
por: Bustin, Katelyn A., et al.
Publicado: (2023)

The TcdE holin drives toxin secretion and virulence in Clostridioides difficile
por: DiBenedetto, NV, et al.
Publicado: (2023)

Anti-virulence strategies for Clostridioides difficile infection: advances and roadblocks
por: Stewart, David, et al.
Publicado: (2020)

Virulence Factors of Clostridioides (Clostridium) difficile Linked to Recurrent Infections
por: Tijerina-Rodríguez, Laura, et al.
Publicado: (2019)

Coordinated modulation of multiple processes through phase variation of a c-di-GMP phosphodiesterase in Clostridioides difficile
por: Reyes Ruiz, Leila M., et al.
Publicado: (2022)

Phase variation of Clostridium difficile virulence factors
por: Anjuwon-Foster, Brandon R., et al.
Publicado: (2017)

Exogenous butyrate inhibits butyrogenic metabolism and alters expression of virulence genes in Clostridioides difficile
por: Pensinger, Daniel A., et al.
Publicado: (2023)

Immune Profiling To Predict Outcome of Clostridioides difficile Infection
por: Abhyankar, Mayuresh M., et al.
Publicado: (2020)

Validation of Clinical Risk Models for Clostridioides difficile-Attributable Outcomes
por: Madden, Gregory R., et al.
Publicado: (2022)

784. A Novel Method to Assess Virulence of Clostridioides difficile: Focus on C. difficile Ribotype 106
por: Almutairi, Masaad, et al.
Publicado: (2020)

Flagellum and toxin phase variation impacts intestinal colonization and disease development in a mouse model of Clostridioides difficile infection
por: Trzilova, Dominika, et al.
Publicado: (2022)

Diagnostic Methods of Clostridioides difficile Infection and Clostridioides difficile Ribotypes in Studied Sample
por: Novakova, Elena, et al.
Publicado: (2021)

Effects of defined gut microbial ecosystem components on virulence determinants of Clostridioides difficile
por: Carlucci, Christian, et al.
Publicado: (2019)

Biological characteristics associated with virulence in Clostridioides difficile ribotype 002 in Hong Kong
por: Kong, Ka Yi, et al.
Publicado: (2020)

Low-toxin Clostridioides difficile RT027 strains exhibit robust virulence
por: Anwar, Farhan, et al.
Publicado: (2022)

Impact of CodY protein on metabolism, sporulation and virulence in Clostridioides difficile ribotype 027
por: Daou, Nadine, et al.
Publicado: (2019)

Lipid Species in the GI Tract are Increased by the Commensal Fungus Candida albicans and Decrease the Virulence of Clostridioides difficile
por: Romo, Jesus A., et al.
Publicado: (2020)

Epidemiology of Clostridioides difficile in South Africa
por: de Jager, Pieter, et al.
Publicado: (2021)

Clostridioides difficile therapeutics: guidelines and beyond
por: Orenstein, Robert, et al.
Publicado: (2019)

71. Diagnostic Stewardship of Clostridioides difficile Testing
por: Qamar, Zahra, et al.
Publicado: (2021)

K-mer based prediction of Clostridioides difficile relatedness and ribotypes
por: Moore, Matthew Phillip, et al.
Publicado: (2022)

Novel and emerging sources of Clostridioides difficile infection
por: Turner, Nicholas A., et al.
Publicado: (2019)

Epidemic ribotypes of Clostridium (now Clostridioides) difficile are likely to be more virulent than non-epidemic ribotypes in animal models
por: Vitucci, John C., et al.
Publicado: (2020)

Iron Regulation in Clostridioides difficile
por: Berges, Mareike, et al.
Publicado: (2018)

Extraintestinal Clostridioides difficile infection
por: Hai, Zhao, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_g9sugiv88o5a4jupaup2cm96pd