Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection

Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates plasma membrane pores that mediate cell lysis and IL-1 cytokine release. Terminal cell lysis and IL-1β release following ca...

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Detalles Bibliográficos
Autores principales: Bjanes, Elisabet, Sillas, Reyna Garcia, Matsuda, Rina, Demarco, Benjamin, Fettrelet, Timothée, DeLaney, Alexandra A., Kornfeld, Opher S., Lee, Bettina L., Rodríguez López, Eric M., Grubaugh, Daniel, Wynosky-Dolfi, Meghan A., Philip, Naomi H., Krespan, Elise, Tovar, Dorothy, Joannas, Leonel, Beiting, Daniel P., Henao-Mejia, Jorge, Schaefer, Brian C., Chen, Kaiwen W., Broz, Petr, Brodsky, Igor E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547626/
https://www.ncbi.nlm.nih.gov/pubmed/34648590
http://dx.doi.org/10.1371/journal.ppat.1009967

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