Adipocytic Glutamine Synthetase Upregulation via Altered Histone Methylation Promotes 5FU Chemoresistance in Peritoneal Carcinomatosis of Colorectal Cancer

The development of resistance to 5-fluorouracil (5FU) chemotherapy is a major handicap for sustained effective treatment in peritoneal carcinomatosis (PC) of colorectal cancer (CRC). Metabolic reprogramming of adipocytes, a component of the tumor microenvironment and the main composition of peritone...

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Detalles Bibliográficos
Autores principales: Zhang, Xuan, Li, Qing, Du, Aibei, Li, Yifei, Shi, Qing, Chen, Yanrong, Zhao, Yang, Wang, Bin, Pan, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547656/
https://www.ncbi.nlm.nih.gov/pubmed/34712612
http://dx.doi.org/10.3389/fonc.2021.748730

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