Cargando…

Assessment of the dose-dependent biochemical and cytotoxicity of zein-coated MgO nanowires in male and female albino rats

Introduction: Recently, zein-coated MgO nanowires were synthesized, which could be promising as an effective antimicrobial compounds that can be combined in the preparation of a diversity of new dental formulations. However, there is a deficiency of information concerning their toxicological profile...

Descripción completa

Detalles Bibliográficos
Autores principales: Naguib, Ghada H., Abd El-Aziz, Gamal S., Mously, Hisham A., Bukhary, Sahar M., Hamed, Mohamed T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547828/
https://www.ncbi.nlm.nih.gov/pubmed/34693843
http://dx.doi.org/10.1080/07853890.2021.1991587
_version_ 1784590455596384256
author Naguib, Ghada H.
Abd El-Aziz, Gamal S.
Mously, Hisham A.
Bukhary, Sahar M.
Hamed, Mohamed T.
author_facet Naguib, Ghada H.
Abd El-Aziz, Gamal S.
Mously, Hisham A.
Bukhary, Sahar M.
Hamed, Mohamed T.
author_sort Naguib, Ghada H.
collection PubMed
description Introduction: Recently, zein-coated MgO nanowires were synthesized, which could be promising as an effective antimicrobial compounds that can be combined in the preparation of a diversity of new dental formulations. However, there is a deficiency of information concerning their toxicological profile regarding the human health. Objective: This in vivo study aimed to explore the hepato- and nephrotoxicity of low versus high doses of zein-coated MgO nanowires in rats. Materials and Methods: A 21-day recurrent dose toxicity research was carried out. Wistar rats were divided into 2 main groups, males and females (n = 18). Each group was further subdivided into 3 subgroups: control, MgO-zein nanowires low dose, MgO-zein nanowires high dose. The low dose used was 100 mg/kg while the high dose used was 200 mg/kg. Results: The results showed that MgO-zein nanowires at both doses did not affect the electrolytes levels compared to the control levels. Also, they did not produce any significant alteration in liver function markers in both rats' genders. MgO-zein nanowires at both doses did not produce any effective alteration in serum creatinine in treated rats of both genders. Moreover, very minimal histological alterations were observed in both doses of MgO-zein nanowires in liver and kidney of both genders. Conclusion: KEY MESSAGES: MgO NPs are globally used in multiple fields including the therapeutic field. Zein has wide pharmaceutical applications especially coating the tablet over sugar. There are no cytotoxic studies that investigate MgO-zein nanowires safety until now.
format Online
Article
Text
id pubmed-8547828
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-85478282021-10-27 Assessment of the dose-dependent biochemical and cytotoxicity of zein-coated MgO nanowires in male and female albino rats Naguib, Ghada H. Abd El-Aziz, Gamal S. Mously, Hisham A. Bukhary, Sahar M. Hamed, Mohamed T. Ann Med Toxicology Introduction: Recently, zein-coated MgO nanowires were synthesized, which could be promising as an effective antimicrobial compounds that can be combined in the preparation of a diversity of new dental formulations. However, there is a deficiency of information concerning their toxicological profile regarding the human health. Objective: This in vivo study aimed to explore the hepato- and nephrotoxicity of low versus high doses of zein-coated MgO nanowires in rats. Materials and Methods: A 21-day recurrent dose toxicity research was carried out. Wistar rats were divided into 2 main groups, males and females (n = 18). Each group was further subdivided into 3 subgroups: control, MgO-zein nanowires low dose, MgO-zein nanowires high dose. The low dose used was 100 mg/kg while the high dose used was 200 mg/kg. Results: The results showed that MgO-zein nanowires at both doses did not affect the electrolytes levels compared to the control levels. Also, they did not produce any significant alteration in liver function markers in both rats' genders. MgO-zein nanowires at both doses did not produce any effective alteration in serum creatinine in treated rats of both genders. Moreover, very minimal histological alterations were observed in both doses of MgO-zein nanowires in liver and kidney of both genders. Conclusion: KEY MESSAGES: MgO NPs are globally used in multiple fields including the therapeutic field. Zein has wide pharmaceutical applications especially coating the tablet over sugar. There are no cytotoxic studies that investigate MgO-zein nanowires safety until now. Taylor & Francis 2021-10-25 /pmc/articles/PMC8547828/ /pubmed/34693843 http://dx.doi.org/10.1080/07853890.2021.1991587 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Toxicology
Naguib, Ghada H.
Abd El-Aziz, Gamal S.
Mously, Hisham A.
Bukhary, Sahar M.
Hamed, Mohamed T.
Assessment of the dose-dependent biochemical and cytotoxicity of zein-coated MgO nanowires in male and female albino rats
title Assessment of the dose-dependent biochemical and cytotoxicity of zein-coated MgO nanowires in male and female albino rats
title_full Assessment of the dose-dependent biochemical and cytotoxicity of zein-coated MgO nanowires in male and female albino rats
title_fullStr Assessment of the dose-dependent biochemical and cytotoxicity of zein-coated MgO nanowires in male and female albino rats
title_full_unstemmed Assessment of the dose-dependent biochemical and cytotoxicity of zein-coated MgO nanowires in male and female albino rats
title_short Assessment of the dose-dependent biochemical and cytotoxicity of zein-coated MgO nanowires in male and female albino rats
title_sort assessment of the dose-dependent biochemical and cytotoxicity of zein-coated mgo nanowires in male and female albino rats
topic Toxicology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547828/
https://www.ncbi.nlm.nih.gov/pubmed/34693843
http://dx.doi.org/10.1080/07853890.2021.1991587
work_keys_str_mv AT naguibghadah assessmentofthedosedependentbiochemicalandcytotoxicityofzeincoatedmgonanowiresinmaleandfemalealbinorats
AT abdelazizgamals assessmentofthedosedependentbiochemicalandcytotoxicityofzeincoatedmgonanowiresinmaleandfemalealbinorats
AT mouslyhishama assessmentofthedosedependentbiochemicalandcytotoxicityofzeincoatedmgonanowiresinmaleandfemalealbinorats
AT bukharysaharm assessmentofthedosedependentbiochemicalandcytotoxicityofzeincoatedmgonanowiresinmaleandfemalealbinorats
AT hamedmohamedt assessmentofthedosedependentbiochemicalandcytotoxicityofzeincoatedmgonanowiresinmaleandfemalealbinorats