Cargando…

Crizotinib and ceritinib trigger immunogenic cell death via on-target effects

Immunogenic cell death (ICD) has initially been discovered in the context of chemotherapy. High-dose crizotinib also stimulates ICD, as we described for non-small cell lung cancer lacking activating chromosomal aberrations of ALK or ROS1, the usual targets of crizotinib, indicating that crizotinib m...

Descripción completa

Detalles Bibliográficos
Autores principales: Petrazzuolo, Adriana, Perez-Lanzon, Maria, Liu, Peng, Maiuri, M. Chiara, Kroemer, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547833/
https://www.ncbi.nlm.nih.gov/pubmed/34712511
http://dx.doi.org/10.1080/2162402X.2021.1973197
Descripción
Sumario:Immunogenic cell death (ICD) has initially been discovered in the context of chemotherapy. High-dose crizotinib also stimulates ICD, as we described for non-small cell lung cancer lacking activating chromosomal aberrations of ALK or ROS1, the usual targets of crizotinib, indicating that crizotinib may act through off-target effects. However, we found that low-dose of ALK inhibitors, crizotinib and ceritinib, may stimulate ICD in anaplastic large cell lymphoma, in which ALK is activated due to a chromosomal translocation, suggesting on target ICD-promoting effects.