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Oscillospira - a candidate for the next-generation probiotics
Oscillospira is a class of organism that often appears in high-throughput sequencing data but has not been purely cultured and is widely present in the animal and human intestines. There is a strong association between variation in Oscillospira abundance and obesity, leanness, and human health. In a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547878/ https://www.ncbi.nlm.nih.gov/pubmed/34693878 http://dx.doi.org/10.1080/19490976.2021.1987783 |
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author | Yang, Jingpeng Li, Yanan Wen, Zhiqiang Liu, Wenzheng Meng, Lingtong Huang, He |
author_facet | Yang, Jingpeng Li, Yanan Wen, Zhiqiang Liu, Wenzheng Meng, Lingtong Huang, He |
author_sort | Yang, Jingpeng |
collection | PubMed |
description | Oscillospira is a class of organism that often appears in high-throughput sequencing data but has not been purely cultured and is widely present in the animal and human intestines. There is a strong association between variation in Oscillospira abundance and obesity, leanness, and human health. In addition, a growing body of studies has shown that Oscillospira is also implicated in other diseases, such as gallstones and chronic constipation, and has shown some correlation with the positive or negative changes in its course. Sequencing data combined with metabolic profiling indicate that Oscillospira is likely to be a genus capable of producing short-chain fatty acids (SCFAs) such as butyrate, which is an important reference indicator for screening “next-generation probiotics “. Considering the positive effects of Oscillospira in some specific diseases, such as obesity-related metabolic diseases, it has already been characterized as one of the next-generation probiotic candidates and therefore has great potential for development and application in the future food, health care, and biopharmaceutical products. |
format | Online Article Text |
id | pubmed-8547878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-85478782021-10-27 Oscillospira - a candidate for the next-generation probiotics Yang, Jingpeng Li, Yanan Wen, Zhiqiang Liu, Wenzheng Meng, Lingtong Huang, He Gut Microbes Review Oscillospira is a class of organism that often appears in high-throughput sequencing data but has not been purely cultured and is widely present in the animal and human intestines. There is a strong association between variation in Oscillospira abundance and obesity, leanness, and human health. In addition, a growing body of studies has shown that Oscillospira is also implicated in other diseases, such as gallstones and chronic constipation, and has shown some correlation with the positive or negative changes in its course. Sequencing data combined with metabolic profiling indicate that Oscillospira is likely to be a genus capable of producing short-chain fatty acids (SCFAs) such as butyrate, which is an important reference indicator for screening “next-generation probiotics “. Considering the positive effects of Oscillospira in some specific diseases, such as obesity-related metabolic diseases, it has already been characterized as one of the next-generation probiotic candidates and therefore has great potential for development and application in the future food, health care, and biopharmaceutical products. Taylor & Francis 2021-10-25 /pmc/articles/PMC8547878/ /pubmed/34693878 http://dx.doi.org/10.1080/19490976.2021.1987783 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Yang, Jingpeng Li, Yanan Wen, Zhiqiang Liu, Wenzheng Meng, Lingtong Huang, He Oscillospira - a candidate for the next-generation probiotics |
title | Oscillospira - a candidate for the next-generation probiotics |
title_full | Oscillospira - a candidate for the next-generation probiotics |
title_fullStr | Oscillospira - a candidate for the next-generation probiotics |
title_full_unstemmed | Oscillospira - a candidate for the next-generation probiotics |
title_short | Oscillospira - a candidate for the next-generation probiotics |
title_sort | oscillospira - a candidate for the next-generation probiotics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547878/ https://www.ncbi.nlm.nih.gov/pubmed/34693878 http://dx.doi.org/10.1080/19490976.2021.1987783 |
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