Hydroxichloroquine for COVID-19 infection: Do we have a final word after one year?

The results presently available from randomised clinical trials and their meta-analysis indicate that Hydroxychloroquine is not associated in COVID-19 patients with either decreased mortality or clinical worsening. Thus, the use of Hydroxychloroquine in COVID-19 patients cannot at present be encoura...

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Detalles Bibliográficos
Autores principales: Di Castelnuovo, Augusto, Costanzo, Simona, Gialluisi, Alessandro, Iacoviello, Licia, de Gaetano, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Federation of Internal Medicine. Published by Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547940/
https://www.ncbi.nlm.nih.gov/pubmed/34750033
http://dx.doi.org/10.1016/j.ejim.2021.10.026
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author Di Castelnuovo, Augusto
Costanzo, Simona
Gialluisi, Alessandro
Iacoviello, Licia
de Gaetano, Giovanni
author_facet Di Castelnuovo, Augusto
Costanzo, Simona
Gialluisi, Alessandro
Iacoviello, Licia
de Gaetano, Giovanni
author_sort Di Castelnuovo, Augusto
collection PubMed
description The results presently available from randomised clinical trials and their meta-analysis indicate that Hydroxychloroquine is not associated in COVID-19 patients with either decreased mortality or clinical worsening. Thus, the use of Hydroxychloroquine in COVID-19 patients cannot at present be encouraged. However, the hypothesis that Hydroxychloroquine might have a beneficial role in subgroups of patients at low risk and/or when used at low dosage (≤ 400 mg/day) deserves to be tested in large, well designed randomised clinical trials.
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spelling pubmed-85479402021-10-27 Hydroxichloroquine for COVID-19 infection: Do we have a final word after one year? Di Castelnuovo, Augusto Costanzo, Simona Gialluisi, Alessandro Iacoviello, Licia de Gaetano, Giovanni Eur J Intern Med Article The results presently available from randomised clinical trials and their meta-analysis indicate that Hydroxychloroquine is not associated in COVID-19 patients with either decreased mortality or clinical worsening. Thus, the use of Hydroxychloroquine in COVID-19 patients cannot at present be encouraged. However, the hypothesis that Hydroxychloroquine might have a beneficial role in subgroups of patients at low risk and/or when used at low dosage (≤ 400 mg/day) deserves to be tested in large, well designed randomised clinical trials. European Federation of Internal Medicine. Published by Elsevier B.V. 2021-12 2021-10-26 /pmc/articles/PMC8547940/ /pubmed/34750033 http://dx.doi.org/10.1016/j.ejim.2021.10.026 Text en © 2021 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Di Castelnuovo, Augusto
Costanzo, Simona
Gialluisi, Alessandro
Iacoviello, Licia
de Gaetano, Giovanni
Hydroxichloroquine for COVID-19 infection: Do we have a final word after one year?
title Hydroxichloroquine for COVID-19 infection: Do we have a final word after one year?
title_full Hydroxichloroquine for COVID-19 infection: Do we have a final word after one year?
title_fullStr Hydroxichloroquine for COVID-19 infection: Do we have a final word after one year?
title_full_unstemmed Hydroxichloroquine for COVID-19 infection: Do we have a final word after one year?
title_short Hydroxichloroquine for COVID-19 infection: Do we have a final word after one year?
title_sort hydroxichloroquine for covid-19 infection: do we have a final word after one year?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547940/
https://www.ncbi.nlm.nih.gov/pubmed/34750033
http://dx.doi.org/10.1016/j.ejim.2021.10.026
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