An open label randomized controlled trial of tamoxifen combined with amphotericin B and fluconazole for cryptococcal meningitis

BACKGROUND: Cryptococcal meningitis has high mortality. Flucytosine is a key treatment but is expensive and rarely available. The anticancer agent tamoxifen has synergistic anti-cryptococcal activity with amphotericin in vitro. It is off-patent, cheap, and widely available. We performed a trial to d...

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Detalles Bibliográficos
Autores principales: Ngan, Nguyen Thi Thuy, Thanh Hoang Le, Nhat, Vi Vi, Nguyen Ngo, Van, Ninh Thi Thanh, Mai, Nguyen Thi Hoang, Van Anh, Duong, Trieu, Phan Hai, Lan, Nguyen Phu Huong, Phu, Nguyen Hoan, Chau, Nguyen Van Vinh, Lalloo, David G, Hope, William, Beardsley, Justin, White, Nicholas J, Geskus, Ronald, Thwaites, Guy E, Krysan, Damian, Tai, Luong Thi Hue, Kestelyn, Evelyne, Binh, Tran Quang, Hung, Le Quoc, Tung, Nguyen Le Nhu, Day, Jeremy N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547950/
https://www.ncbi.nlm.nih.gov/pubmed/34581270
http://dx.doi.org/10.7554/eLife.68929

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