Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites

Most eukaryotic cells retain a mitochondrial fatty acid synthesis (FASII) pathway whose acyl carrier protein (mACP) and 4-phosphopantetheine (Ppant) prosthetic group provide a soluble scaffold for acyl chain synthesis and biochemically couple FASII activity to mitochondrial electron transport chain...

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Detalles Bibliográficos
Autores principales: Falekun, Seyi, Sepulveda, Jaime, Jami-Alahmadi, Yasaman, Park, Hahnbeom, Wohlschlegel, James A, Sigala, Paul A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547962/
https://www.ncbi.nlm.nih.gov/pubmed/34612205
http://dx.doi.org/10.7554/eLife.71636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547962/
https://www.ncbi.nlm.nih.gov/pubmed/34612205
http://dx.doi.org/10.7554/eLife.71636

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