Cargando…

Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites

Most eukaryotic cells retain a mitochondrial fatty acid synthesis (FASII) pathway whose acyl carrier protein (mACP) and 4-phosphopantetheine (Ppant) prosthetic group provide a soluble scaffold for acyl chain synthesis and biochemically couple FASII activity to mitochondrial electron transport chain...

Descripción completa

Detalles Bibliográficos
Autores principales:	Falekun, Seyi, Sepulveda, Jaime, Jami-Alahmadi, Yasaman, Park, Hahnbeom, Wohlschlegel, James A, Sigala, Paul A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547962/ https://www.ncbi.nlm.nih.gov/pubmed/34612205 http://dx.doi.org/10.7554/eLife.71636

Ejemplares similares

Critical role for isoprenoids in apicoplast biogenesis by malaria parasites
por: Okada, Megan, et al.
Publicado: (2022)

The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis
por: Van Vranken, Jonathan G, et al.
Publicado: (2016)

An ER translocon for multi-pass membrane protein biogenesis
por: McGilvray, Philip T, et al.
Publicado: (2020)

Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness
por: Tye, Blake W, et al.
Publicado: (2019)

Acyl chain asymmetry and polyunsaturation of brain phospholipids facilitate membrane vesiculation without leakage
por: Manni, Marco M, et al.
Publicado: (2018)

SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a
por: Jing, Hui, et al.
Publicado: (2017)

Cooperative enzymatic control of N-acyl amino acids by PM20D1 and FAAH
por: Kim, Joon T, et al.
Publicado: (2020)

Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system
por: Icke, Christopher, et al.
Publicado: (2021)

Deconvoluting heme biosynthesis to target blood-stage malaria parasites
por: Sigala, Paul A, et al.
Publicado: (2015)

Structural insight on the mechanism of an electron-bifurcating [FeFe] hydrogenase
por: Furlan, Chris, et al.
Publicado: (2022)

Inter-membrane association of the Sec and BAM translocons for bacterial outer-membrane biogenesis
por: Alvira, Sara, et al.
Publicado: (2020)

A novel fold for acyltransferase-3 (AT3) proteins provides a framework for transmembrane acyl-group transfer
por: Newman, Kahlan E, et al.
Publicado: (2023)

Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens
por: Amberg-Johnson, Katherine, et al.
Publicado: (2017)

COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis
por: Aich, Abhishek, et al.
Publicado: (2018)

Immunoproteasome functions explained by divergence in cleavage specificity and regulation
por: Winter, Michael B, et al.
Publicado: (2017)

A network of cytosolic (co)chaperones promotes the biogenesis of mitochondrial signal-anchored outer membrane proteins
por: Drwesh, Layla, et al.
Publicado: (2022)

Iron-regulated assembly of the cytosolic iron–sulfur cluster biogenesis machinery
por: Fan, Xiaorui, et al.
Publicado: (2022)

A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation
por: Patil, Gajanan S, et al.
Publicado: (2021)

Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis
por: Panic, Vanja, et al.
Publicado: (2020)

Divergent Cl(-) and H(+) pathways underlie transport coupling and gating in CLC exchangers and channels
por: Leisle, Lilia, et al.
Publicado: (2020)

Selenocyanate derived Se-incorporation into the nitrogenase Fe protein cluster
por: Buscagan, Trixia M, et al.
Publicado: (2022)

Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase
por: Wittenborn, Elizabeth C, et al.
Publicado: (2018)

Emergence and diversification of a host-parasite RNA ecosystem through Darwinian evolution
por: Furubayashi, Taro, et al.
Publicado: (2020)

Integration of IL-2 and IL-4 signals coordinates divergent regulatory T cell responses and drives therapeutic efficacy
por: Zhou, Julie Y, et al.
Publicado: (2021)

Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex
por: Zou, Xinle, et al.
Publicado: (2023)

A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite
por: Ramaprasad, Abhinay, et al.
Publicado: (2022)

A parasitic fungus employs mutated eIF4A to survive on rocaglate-synthesizing Aglaia plants
por: Chen, Mingming, et al.
Publicado: (2023)

Mechanisms of iron- and O(2)-sensing by the [4Fe-4S] cluster of the global iron regulator RirA
por: Pellicer Martinez, Ma Teresa, et al.
Publicado: (2019)

Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia
por: Hu, Xuchen, et al.
Publicado: (2019)

Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function
por: Morck, Makenna M, et al.
Publicado: (2022)

The interdependence of isoprenoid synthesis and apicoplast biogenesis in malaria parasites
por: Okada, Megan, et al.
Publicado: (2023)

Discovery of a small molecule that inhibits bacterial ribosome biogenesis
por: Stokes, Jonathan M, et al.
Publicado: (2014)

Protein biogenesis machinery is a driver of replicative aging in yeast
por: Janssens, Georges E, et al.
Publicado: (2015)

SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation
por: Zhang, Xiaoyu, et al.
Publicado: (2017)

Direct Tests of Cytochrome Function in the Electron Transport Chain of Malaria Parasites
por: Espino-Sanchez, Tanya J., et al.
Publicado: (2023)

High-Field Asymmetric Waveform Ion Mobility Spectrometry Interface Enhances Parallel Reaction Monitoring on an Orbitrap Mass Spectrometer
por: Deng, Weixian, et al.
Publicado: (2022)

Correction: Structure-guided microbial targeting of antistaphylococcal prodrugs
por: Miller, Justin J, et al.
Publicado: (2021)

Structure-guided microbial targeting of antistaphylococcal prodrugs
por: Miller, Justin J, et al.
Publicado: (2021)

Artemisinin mimics calorie restriction to trigger mitochondrial biogenesis and compromise telomere shortening in mice
por: Wang, Da-Ting, et al.
Publicado: (2015)

Mitochondrial destiny in type 2 diabetes: the effects of oxidative stress on the dynamics and biogenesis of mitochondria
por: Skuratovskaia, Daria, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5t8fkkjln09caot9f6lh66ib21