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Retinal adaptive optics imaging with a pyramid wavefront sensor

The pyramid wavefront sensor (P-WFS) has replaced the Shack-Hartmann (SH-) WFS as the sensor of choice for high-performance adaptive optics (AO) systems in astronomy. Many advantages of the P-WFS, such as its adjustable pupil sampling and superior sensitivity, are potentially of great benefit for AO...

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Autores principales: Brunner, Elisabeth, Shatokhina, Julia, Shirazi, Muhammad Faizan, Drexler, Wolfgang, Leitgeb, Rainer, Pollreisz, Andreas, Hitzenberger, Christoph K., Ramlau, Ronny, Pircher, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548025/
https://www.ncbi.nlm.nih.gov/pubmed/34745716
http://dx.doi.org/10.1364/BOE.438915
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author Brunner, Elisabeth
Shatokhina, Julia
Shirazi, Muhammad Faizan
Drexler, Wolfgang
Leitgeb, Rainer
Pollreisz, Andreas
Hitzenberger, Christoph K.
Ramlau, Ronny
Pircher, Michael
author_facet Brunner, Elisabeth
Shatokhina, Julia
Shirazi, Muhammad Faizan
Drexler, Wolfgang
Leitgeb, Rainer
Pollreisz, Andreas
Hitzenberger, Christoph K.
Ramlau, Ronny
Pircher, Michael
author_sort Brunner, Elisabeth
collection PubMed
description The pyramid wavefront sensor (P-WFS) has replaced the Shack-Hartmann (SH-) WFS as the sensor of choice for high-performance adaptive optics (AO) systems in astronomy. Many advantages of the P-WFS, such as its adjustable pupil sampling and superior sensitivity, are potentially of great benefit for AO-supported imaging in ophthalmology as well. However, so far no high quality ophthalmic AO imaging was achieved using this novel sensor. Usually, a P-WFS requires modulation and high precision optics that lead to high complexity and costs of the sensor. These factors limit the competitiveness of the P-WFS with respect to other WFS devices for AO correction in visual science. Here, we present a cost-effective realization of AO correction with a non-modulated P-WFS based on standard components and apply this technique to human retinal in vivo imaging using optical coherence tomography (OCT). P-WFS based high quality AO imaging was successfully performed in 5 healthy subjects and smallest retinal cells such as central foveal cone photoreceptors are visualized. The robustness and versatility of the sensor is demonstrated in the model eye under various conditions and in vivo by high-resolution imaging of other structures in the retina using standard and extended fields of view. As a quality benchmark, the performance of conventional SH-WFS based AO was used and successfully met. This work may trigger a paradigm shift with respect to the wavefront sensor of choice for AO in ophthalmic imaging.
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spelling pubmed-85480252021-11-05 Retinal adaptive optics imaging with a pyramid wavefront sensor Brunner, Elisabeth Shatokhina, Julia Shirazi, Muhammad Faizan Drexler, Wolfgang Leitgeb, Rainer Pollreisz, Andreas Hitzenberger, Christoph K. Ramlau, Ronny Pircher, Michael Biomed Opt Express Article The pyramid wavefront sensor (P-WFS) has replaced the Shack-Hartmann (SH-) WFS as the sensor of choice for high-performance adaptive optics (AO) systems in astronomy. Many advantages of the P-WFS, such as its adjustable pupil sampling and superior sensitivity, are potentially of great benefit for AO-supported imaging in ophthalmology as well. However, so far no high quality ophthalmic AO imaging was achieved using this novel sensor. Usually, a P-WFS requires modulation and high precision optics that lead to high complexity and costs of the sensor. These factors limit the competitiveness of the P-WFS with respect to other WFS devices for AO correction in visual science. Here, we present a cost-effective realization of AO correction with a non-modulated P-WFS based on standard components and apply this technique to human retinal in vivo imaging using optical coherence tomography (OCT). P-WFS based high quality AO imaging was successfully performed in 5 healthy subjects and smallest retinal cells such as central foveal cone photoreceptors are visualized. The robustness and versatility of the sensor is demonstrated in the model eye under various conditions and in vivo by high-resolution imaging of other structures in the retina using standard and extended fields of view. As a quality benchmark, the performance of conventional SH-WFS based AO was used and successfully met. This work may trigger a paradigm shift with respect to the wavefront sensor of choice for AO in ophthalmic imaging. Optical Society of America 2021-09-02 /pmc/articles/PMC8548025/ /pubmed/34745716 http://dx.doi.org/10.1364/BOE.438915 Text en Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. https://creativecommons.org/licenses/by/4.0/https://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Brunner, Elisabeth
Shatokhina, Julia
Shirazi, Muhammad Faizan
Drexler, Wolfgang
Leitgeb, Rainer
Pollreisz, Andreas
Hitzenberger, Christoph K.
Ramlau, Ronny
Pircher, Michael
Retinal adaptive optics imaging with a pyramid wavefront sensor
title Retinal adaptive optics imaging with a pyramid wavefront sensor
title_full Retinal adaptive optics imaging with a pyramid wavefront sensor
title_fullStr Retinal adaptive optics imaging with a pyramid wavefront sensor
title_full_unstemmed Retinal adaptive optics imaging with a pyramid wavefront sensor
title_short Retinal adaptive optics imaging with a pyramid wavefront sensor
title_sort retinal adaptive optics imaging with a pyramid wavefront sensor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548025/
https://www.ncbi.nlm.nih.gov/pubmed/34745716
http://dx.doi.org/10.1364/BOE.438915
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