Supplementation with Branched-Chain Amino Acids Induces Unexpected Deleterious Effects on Astrocyte Survival and Intracellular Metabolism with or without Hyperammonemia: A Preliminary In Vitro Study

INTRODUCTION: Ammonia is a key component in the pathogenesis of hepatic encephalopathy. Branched-chain amino acids (BCAA) have been reported to improve the symptoms of HE induced by hyperammonemia; however, we recently reported that ammonia increases intracellular levels of BCAA and exerts toxic eff...

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Detalles Bibliográficos
Autores principales: Wang, Ting, Suzuki, Kazuyuki, Chiba, Toshimi, Kakisaka, Keisuke, Takikawa, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548177/
https://www.ncbi.nlm.nih.gov/pubmed/34712496
http://dx.doi.org/10.1155/2021/7615126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548177/
https://www.ncbi.nlm.nih.gov/pubmed/34712496
http://dx.doi.org/10.1155/2021/7615126

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