Clinical Practice Guidelines for Pre-Analytical Procedures of Plasma Epidermal Growth Factor Receptor Variant Testing

Standardization of cell-free DNA (cfDNA) testing processes is necessary to obtain clinically reliable results. The pre-analytical phase of cfDNA testing greatly influences the results because of the low proportion and stability of circulating tumor DNA (ctDNA). In this review, we provide evidence-ba...

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Autores principales: Shin, Saeam, Woo, Hye In, Kim, Jong-Won, Kim, Yoonjung, Lee, Kyung-A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Laboratory Medicine 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548242/
https://www.ncbi.nlm.nih.gov/pubmed/34635607
http://dx.doi.org/10.3343/alm.2022.42.2.141
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author Shin, Saeam
Woo, Hye In
Kim, Jong-Won
Kim, Yoonjung
Lee, Kyung-A
author_facet Shin, Saeam
Woo, Hye In
Kim, Jong-Won
Kim, Yoonjung
Lee, Kyung-A
author_sort Shin, Saeam
collection PubMed
description Standardization of cell-free DNA (cfDNA) testing processes is necessary to obtain clinically reliable results. The pre-analytical phase of cfDNA testing greatly influences the results because of the low proportion and stability of circulating tumor DNA (ctDNA). In this review, we provide evidence-based clinical practice guidelines for pre-analytical phase procedures of plasma epidermal growth factor receptor gene (EGFR) variant testing. Specific recommendations for pre-analytical procedures were proposed based on evidence from the literature and our experimental data. Standardization of pre-analytical procedures can improve the analytical performance of cfDNA testing.
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spelling pubmed-85482422022-03-01 Clinical Practice Guidelines for Pre-Analytical Procedures of Plasma Epidermal Growth Factor Receptor Variant Testing Shin, Saeam Woo, Hye In Kim, Jong-Won Kim, Yoonjung Lee, Kyung-A Ann Lab Med Review Article Standardization of cell-free DNA (cfDNA) testing processes is necessary to obtain clinically reliable results. The pre-analytical phase of cfDNA testing greatly influences the results because of the low proportion and stability of circulating tumor DNA (ctDNA). In this review, we provide evidence-based clinical practice guidelines for pre-analytical phase procedures of plasma epidermal growth factor receptor gene (EGFR) variant testing. Specific recommendations for pre-analytical procedures were proposed based on evidence from the literature and our experimental data. Standardization of pre-analytical procedures can improve the analytical performance of cfDNA testing. Korean Society for Laboratory Medicine 2022-03-01 2022-03-01 /pmc/articles/PMC8548242/ /pubmed/34635607 http://dx.doi.org/10.3343/alm.2022.42.2.141 Text en © Korean Society for Laboratory Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shin, Saeam
Woo, Hye In
Kim, Jong-Won
Kim, Yoonjung
Lee, Kyung-A
Clinical Practice Guidelines for Pre-Analytical Procedures of Plasma Epidermal Growth Factor Receptor Variant Testing
title Clinical Practice Guidelines for Pre-Analytical Procedures of Plasma Epidermal Growth Factor Receptor Variant Testing
title_full Clinical Practice Guidelines for Pre-Analytical Procedures of Plasma Epidermal Growth Factor Receptor Variant Testing
title_fullStr Clinical Practice Guidelines for Pre-Analytical Procedures of Plasma Epidermal Growth Factor Receptor Variant Testing
title_full_unstemmed Clinical Practice Guidelines for Pre-Analytical Procedures of Plasma Epidermal Growth Factor Receptor Variant Testing
title_short Clinical Practice Guidelines for Pre-Analytical Procedures of Plasma Epidermal Growth Factor Receptor Variant Testing
title_sort clinical practice guidelines for pre-analytical procedures of plasma epidermal growth factor receptor variant testing
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548242/
https://www.ncbi.nlm.nih.gov/pubmed/34635607
http://dx.doi.org/10.3343/alm.2022.42.2.141
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