Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline

Telomerase extends chromosome ends in somatic and germline stem cells to ensure continued proliferation. Mutations in genes critical for telomerase function result in telomeropathies such as dyskeratosis congenita, frequently resulting in spontaneous bone marrow failure. A dyskeratosis congenita mut...

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Detalles Bibliográficos
Autores principales: Graniel, Jacqueline V, Bisht, Kamlesh, Friedman, Ann, White, James, Perkey, Eric, Vanderbeck, Ashley, Moroz, Alina, Carrington, Léolène J, Brandstadter, Joshua D, Allen, Frederick, Shami, Adrienne Niederriter, Thomas, Peedikayil, Crayton, Aniela, Manzor, Mariel, Mychalowych, Anna, Chase, Jennifer, Hammoud, Saher S, Keegan, Catherine E, Maillard, Ivan, Nandakumar, Jayakrishnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548261/
https://www.ncbi.nlm.nih.gov/pubmed/34645668
http://dx.doi.org/10.26508/lsa.202101208

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