PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands

DNA methylation at enhancers and CpG islands usually leads to gene repression, which is counteracted by DNA demethylation through the TET protein family. However, how TET enzymes are recruited and regulated at these genomic loci is not fully understood. Here, we identify TET2, the glycosyltransferas...

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Detalles Bibliográficos
Autores principales: Wang, Xiaokang, Rosikiewicz, Wojciech, Sedkov, Yurii, Martinez, Tanner, Hansen, Baranda S, Schreiner, Patrick, Christensen, Jesper, Xu, Beisi, Pruett-Miller, Shondra M, Helin, Kristian, Herz, Hans-Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548262/
https://www.ncbi.nlm.nih.gov/pubmed/34667079
http://dx.doi.org/10.26508/lsa.202101228

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