Large cell neuroendocrine lung carcinoma: consensus statement from The British Thoracic Oncology Group and the Association of Pulmonary Pathologists

Over the past 10 years, lung cancer clinical and translational research has been characterised by exponential progress, exemplified by the introduction of molecularly targeted therapies, immunotherapy and chemo-immunotherapy combinations to stage III and IV non-small cell lung cancer. Along with squ...

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Detalles Bibliográficos
Autores principales: Lindsay, Colin R., Shaw, Emily C., Moore, David A., Rassl, Doris, Jamal-Hanjani, Mariam, Steele, Nicola, Naheed, Salma, Dick, Craig, Taylor, Fiona, Adderley, Helen, Black, Fiona, Summers, Yvonne, Evans, Matt, Rice, Alexandra, Fabre, Aurelie, Wallace, William A., Nicholson, Siobhan, Haragan, Alex, Taniere, Phillipe, Nicholson, Andrew G., Laing, Gavin, Cave, Judith, Forster, Martin D., Blackhall, Fiona, Gosney, John, Popat, Sanjay, Kerr, Keith M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Consensus Statement
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548341/
https://www.ncbi.nlm.nih.gov/pubmed/34489586
http://dx.doi.org/10.1038/s41416-021-01407-9
Descripción
Sumario:Over the past 10 years, lung cancer clinical and translational research has been characterised by exponential progress, exemplified by the introduction of molecularly targeted therapies, immunotherapy and chemo-immunotherapy combinations to stage III and IV non-small cell lung cancer. Along with squamous and small cell lung cancers, large cell neuroendocrine carcinoma (LCNEC) now represents an area of unmet need, particularly hampered by the lack of an encompassing pathological definition that can facilitate real-world and clinical trial progress. The steps we have proposed in this article represent an iterative and rational path forward towards clinical breakthroughs that can be modelled on success in other lung cancer pathologies.

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