Miniature type V-F CRISPR-Cas nucleases enable targeted DNA modification in cells

Class 2 CRISPR systems are exceptionally diverse, nevertheless, all share a single effector protein that contains a conserved RuvC-like nuclease domain. Interestingly, the size of these CRISPR-associated (Cas) nucleases ranges from >1000 amino acids (aa) for Cas9/Cas12a to as small as 400-600 aa...

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Detalles Bibliográficos
Autores principales: Bigelyte, Greta, Young, Joshua K., Karvelis, Tautvydas, Budre, Karolina, Zedaveinyte, Rimante, Djukanovic, Vesna, Van Ginkel, Elizabeth, Paulraj, Sushmitha, Gasior, Stephen, Jones, Spencer, Feigenbutz, Lanie, Clair, Grace St., Barone, Pierluigi, Bohn, Jennifer, Acharya, Ananta, Zastrow-Hayes, Gina, Henkel-Heinecke, Selgar, Silanskas, Arunas, Seidel, Ralf, Siksnys, Virginijus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548392/
https://www.ncbi.nlm.nih.gov/pubmed/34702830
http://dx.doi.org/10.1038/s41467-021-26469-4

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