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Acute Myeloid Leukemia Epigenetic Immune Escape From Nature Killer Cells by ICAM-1
Acute myeloid leukemia (AML), a malignant disorder of hemopoietic stem cells. AML can escape immunosurveillance of natural killer (NK) by gene mutation, fusions, and epigenetic modification, while the mechanism is not clearly understood. Here we show that the expression of Intercellular adhesion mol...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548470/ https://www.ncbi.nlm.nih.gov/pubmed/34722306 http://dx.doi.org/10.3389/fonc.2021.751834 |
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author | Xiao, Yang Chen, Jinghong Wang, Jia Guan, Wei Wang, Mengzhen Zhang, Linlin Wang, Zhiding Wang, Lixin Yu, Li |
author_facet | Xiao, Yang Chen, Jinghong Wang, Jia Guan, Wei Wang, Mengzhen Zhang, Linlin Wang, Zhiding Wang, Lixin Yu, Li |
author_sort | Xiao, Yang |
collection | PubMed |
description | Acute myeloid leukemia (AML), a malignant disorder of hemopoietic stem cells. AML can escape immunosurveillance of natural killer (NK) by gene mutation, fusions, and epigenetic modification, while the mechanism is not clearly understood. Here we show that the expression of Intercellular adhesion molecule‐1 (ICAM‐1, CD54) is silenced in AML cells. Decitabine could upregulate ICAM-1 expression, which contributes to the NK-AML cell conjugates and helps NK cells kill AML cells. We also show that ICAM-1 high expression can reverse the AML immune evasion and activate NK cells function in vivo. This study suggests that a combination of the hypomethylating agent and NK cell infusion could be a new strategy to cure AML. |
format | Online Article Text |
id | pubmed-8548470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85484702021-10-28 Acute Myeloid Leukemia Epigenetic Immune Escape From Nature Killer Cells by ICAM-1 Xiao, Yang Chen, Jinghong Wang, Jia Guan, Wei Wang, Mengzhen Zhang, Linlin Wang, Zhiding Wang, Lixin Yu, Li Front Oncol Oncology Acute myeloid leukemia (AML), a malignant disorder of hemopoietic stem cells. AML can escape immunosurveillance of natural killer (NK) by gene mutation, fusions, and epigenetic modification, while the mechanism is not clearly understood. Here we show that the expression of Intercellular adhesion molecule‐1 (ICAM‐1, CD54) is silenced in AML cells. Decitabine could upregulate ICAM-1 expression, which contributes to the NK-AML cell conjugates and helps NK cells kill AML cells. We also show that ICAM-1 high expression can reverse the AML immune evasion and activate NK cells function in vivo. This study suggests that a combination of the hypomethylating agent and NK cell infusion could be a new strategy to cure AML. Frontiers Media S.A. 2021-10-13 /pmc/articles/PMC8548470/ /pubmed/34722306 http://dx.doi.org/10.3389/fonc.2021.751834 Text en Copyright © 2021 Xiao, Chen, Wang, Guan, Wang, Zhang, Wang, Wang and Yu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Xiao, Yang Chen, Jinghong Wang, Jia Guan, Wei Wang, Mengzhen Zhang, Linlin Wang, Zhiding Wang, Lixin Yu, Li Acute Myeloid Leukemia Epigenetic Immune Escape From Nature Killer Cells by ICAM-1 |
title | Acute Myeloid Leukemia Epigenetic Immune Escape From Nature Killer Cells by ICAM-1 |
title_full | Acute Myeloid Leukemia Epigenetic Immune Escape From Nature Killer Cells by ICAM-1 |
title_fullStr | Acute Myeloid Leukemia Epigenetic Immune Escape From Nature Killer Cells by ICAM-1 |
title_full_unstemmed | Acute Myeloid Leukemia Epigenetic Immune Escape From Nature Killer Cells by ICAM-1 |
title_short | Acute Myeloid Leukemia Epigenetic Immune Escape From Nature Killer Cells by ICAM-1 |
title_sort | acute myeloid leukemia epigenetic immune escape from nature killer cells by icam-1 |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548470/ https://www.ncbi.nlm.nih.gov/pubmed/34722306 http://dx.doi.org/10.3389/fonc.2021.751834 |
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