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Intubated COVID-19 predictive (ICOP) score for early mortality after intubation in patients with COVID-19
Patients with coronavirus disease 2019 (COVID-19) can have increased risk of mortality shortly after intubation. The aim of this study is to develop a model using predictors of early mortality after intubation from COVID-19. A retrospective study of 1945 intubated patients with COVID-19 admitted to...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548515/ https://www.ncbi.nlm.nih.gov/pubmed/34702896 http://dx.doi.org/10.1038/s41598-021-00591-1 |
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author | Nishikimi, Mitsuaki Rasul, Rehana Sison, Cristina P. Jafari, Daniel Shoaib, Muhammad Shinozaki, Koichiro Li, Timmy Hayashida, Kei Rolston, Daniel M. Hirsch, Jamie S. Becker, Lance B. |
author_facet | Nishikimi, Mitsuaki Rasul, Rehana Sison, Cristina P. Jafari, Daniel Shoaib, Muhammad Shinozaki, Koichiro Li, Timmy Hayashida, Kei Rolston, Daniel M. Hirsch, Jamie S. Becker, Lance B. |
author_sort | Nishikimi, Mitsuaki |
collection | PubMed |
description | Patients with coronavirus disease 2019 (COVID-19) can have increased risk of mortality shortly after intubation. The aim of this study is to develop a model using predictors of early mortality after intubation from COVID-19. A retrospective study of 1945 intubated patients with COVID-19 admitted to 12 Northwell hospitals in the greater New York City area was performed. Logistic regression model using backward selection was applied. This study evaluated predictors of 14-day mortality after intubation for COVID-19 patients. The predictors of mortality within 14 days after intubation included older age, history of chronic kidney disease, lower mean arterial pressure or increased dose of required vasopressors, higher urea nitrogen level, higher ferritin, higher oxygen index, and abnormal pH levels. We developed and externally validated an intubated COVID-19 predictive score (ICOP). The area under the receiver operating characteristic curve was 0.75 (95% CI 0.73–0.78) in the derivation cohort and 0.71 (95% CI 0.67–0.75) in the validation cohort; both were significantly greater than corresponding values for sequential organ failure assessment (SOFA) or CURB-65 scores. The externally validated predictive score may help clinicians estimate early mortality risk after intubation and provide guidance for deciding the most effective patient therapies. |
format | Online Article Text |
id | pubmed-8548515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-85485152021-10-28 Intubated COVID-19 predictive (ICOP) score for early mortality after intubation in patients with COVID-19 Nishikimi, Mitsuaki Rasul, Rehana Sison, Cristina P. Jafari, Daniel Shoaib, Muhammad Shinozaki, Koichiro Li, Timmy Hayashida, Kei Rolston, Daniel M. Hirsch, Jamie S. Becker, Lance B. Sci Rep Article Patients with coronavirus disease 2019 (COVID-19) can have increased risk of mortality shortly after intubation. The aim of this study is to develop a model using predictors of early mortality after intubation from COVID-19. A retrospective study of 1945 intubated patients with COVID-19 admitted to 12 Northwell hospitals in the greater New York City area was performed. Logistic regression model using backward selection was applied. This study evaluated predictors of 14-day mortality after intubation for COVID-19 patients. The predictors of mortality within 14 days after intubation included older age, history of chronic kidney disease, lower mean arterial pressure or increased dose of required vasopressors, higher urea nitrogen level, higher ferritin, higher oxygen index, and abnormal pH levels. We developed and externally validated an intubated COVID-19 predictive score (ICOP). The area under the receiver operating characteristic curve was 0.75 (95% CI 0.73–0.78) in the derivation cohort and 0.71 (95% CI 0.67–0.75) in the validation cohort; both were significantly greater than corresponding values for sequential organ failure assessment (SOFA) or CURB-65 scores. The externally validated predictive score may help clinicians estimate early mortality risk after intubation and provide guidance for deciding the most effective patient therapies. Nature Publishing Group UK 2021-10-26 /pmc/articles/PMC8548515/ /pubmed/34702896 http://dx.doi.org/10.1038/s41598-021-00591-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Nishikimi, Mitsuaki Rasul, Rehana Sison, Cristina P. Jafari, Daniel Shoaib, Muhammad Shinozaki, Koichiro Li, Timmy Hayashida, Kei Rolston, Daniel M. Hirsch, Jamie S. Becker, Lance B. Intubated COVID-19 predictive (ICOP) score for early mortality after intubation in patients with COVID-19 |
title | Intubated COVID-19 predictive (ICOP) score for early mortality after intubation in patients with COVID-19 |
title_full | Intubated COVID-19 predictive (ICOP) score for early mortality after intubation in patients with COVID-19 |
title_fullStr | Intubated COVID-19 predictive (ICOP) score for early mortality after intubation in patients with COVID-19 |
title_full_unstemmed | Intubated COVID-19 predictive (ICOP) score for early mortality after intubation in patients with COVID-19 |
title_short | Intubated COVID-19 predictive (ICOP) score for early mortality after intubation in patients with COVID-19 |
title_sort | intubated covid-19 predictive (icop) score for early mortality after intubation in patients with covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548515/ https://www.ncbi.nlm.nih.gov/pubmed/34702896 http://dx.doi.org/10.1038/s41598-021-00591-1 |
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