A combined treatment regimen of MGMT-modified γδ T cells and temozolomide chemotherapy is effective against primary high grade gliomas

Chemotherapeutic drugs such as the alkylating agent Temozolomide (TMZ), in addition to reducing tumor mass, can also sensitize tumors to immune recognition by transient upregulation of multiple stress induced NKG2D ligands (NKG2DL). However, the potential for an effective response by innate lymphocy...

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Detalles Bibliográficos
Autores principales: Lamb, Lawrence S., Pereboeva, Larisa, Youngblood, Samantha, Gillespie, G. Yancey, Nabors, L. Burton, Markert, James M., Dasgupta, Anindya, Langford, Catherine, Spencer, H. Trent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548550/
https://www.ncbi.nlm.nih.gov/pubmed/34702850
http://dx.doi.org/10.1038/s41598-021-00536-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548550/
https://www.ncbi.nlm.nih.gov/pubmed/34702850
http://dx.doi.org/10.1038/s41598-021-00536-8

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