Clinical Application of Adaptive Immune Therapy in MSS Colorectal Cancer Patients

Colorectal cancer (CRC) is one of the most common cancers worldwide. However, the treatment outcomes of immunotherapy in microsatellite-stable (MSS) CRC remain unsatisfactory. As the majority of CRC cases display a molecular MSS/mismatch repair-proficient (pMMR) profile, it is particularly meaningfu...

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Autores principales: Wang, Danyang, Zhang, Hangyu, Xiang, Tao, Wang, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548603/
https://www.ncbi.nlm.nih.gov/pubmed/34721435
http://dx.doi.org/10.3389/fimmu.2021.762341
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author Wang, Danyang
Zhang, Hangyu
Xiang, Tao
Wang, Gang
author_facet Wang, Danyang
Zhang, Hangyu
Xiang, Tao
Wang, Gang
author_sort Wang, Danyang
collection PubMed
description Colorectal cancer (CRC) is one of the most common cancers worldwide. However, the treatment outcomes of immunotherapy in microsatellite-stable (MSS) CRC remain unsatisfactory. As the majority of CRC cases display a molecular MSS/mismatch repair-proficient (pMMR) profile, it is particularly meaningful to explore the clinical applications of adaptive immune therapy in MSS CRC patients. In this review, we summarized the therapeutic approaches of adoptive immune therapies, including cytokines, therapeutic cancer vaccines, adoptive T-cell therapy, and immune checkpoint inhibitors, in the treatment of MSS CRCs.
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spelling pubmed-85486032021-10-28 Clinical Application of Adaptive Immune Therapy in MSS Colorectal Cancer Patients Wang, Danyang Zhang, Hangyu Xiang, Tao Wang, Gang Front Immunol Immunology Colorectal cancer (CRC) is one of the most common cancers worldwide. However, the treatment outcomes of immunotherapy in microsatellite-stable (MSS) CRC remain unsatisfactory. As the majority of CRC cases display a molecular MSS/mismatch repair-proficient (pMMR) profile, it is particularly meaningful to explore the clinical applications of adaptive immune therapy in MSS CRC patients. In this review, we summarized the therapeutic approaches of adoptive immune therapies, including cytokines, therapeutic cancer vaccines, adoptive T-cell therapy, and immune checkpoint inhibitors, in the treatment of MSS CRCs. Frontiers Media S.A. 2021-10-13 /pmc/articles/PMC8548603/ /pubmed/34721435 http://dx.doi.org/10.3389/fimmu.2021.762341 Text en Copyright © 2021 Wang, Zhang, Xiang and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Danyang
Zhang, Hangyu
Xiang, Tao
Wang, Gang
Clinical Application of Adaptive Immune Therapy in MSS Colorectal Cancer Patients
title Clinical Application of Adaptive Immune Therapy in MSS Colorectal Cancer Patients
title_full Clinical Application of Adaptive Immune Therapy in MSS Colorectal Cancer Patients
title_fullStr Clinical Application of Adaptive Immune Therapy in MSS Colorectal Cancer Patients
title_full_unstemmed Clinical Application of Adaptive Immune Therapy in MSS Colorectal Cancer Patients
title_short Clinical Application of Adaptive Immune Therapy in MSS Colorectal Cancer Patients
title_sort clinical application of adaptive immune therapy in mss colorectal cancer patients
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548603/
https://www.ncbi.nlm.nih.gov/pubmed/34721435
http://dx.doi.org/10.3389/fimmu.2021.762341
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AT xiangtao clinicalapplicationofadaptiveimmunetherapyinmsscolorectalcancerpatients
AT wanggang clinicalapplicationofadaptiveimmunetherapyinmsscolorectalcancerpatients

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