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Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can
Severe status of coronavirus disease 2019 (COVID-19) is extremely associated to cytokine release. Moreover, it has been suggested that blood group is also associated with the prevalence and severity of this disease. However, the relationship between the cytokine profile and blood group remains uncle...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548690/ https://www.ncbi.nlm.nih.gov/pubmed/34721388 http://dx.doi.org/10.3389/fimmu.2021.726283 |
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author | Tamayo-Velasco, Álvaro Peñarrubia Ponce, María Jesús Álvarez, Francisco Javier Gonzalo-Benito, Hugo de la Fuente, Ignacio Pérez-González, Sonia Rico, Lucía Jiménez García, María Teresa Sánchez Rodríguez, Alba Hijas Villaizan, Milagros Martín-Fernández, Marta Dueñas, Carlos Gómez-Sánchez, Esther Heredia-Rodríguez, María Gorgojo-Galindo, Óscar Fernández, Itziar del Río, Lourdes Carnicero-Frutos, Irene Muñoz-Moreno, María Fe Tamayo, Eduardo Bernardo, David Martínez-Paz, Pedro |
author_facet | Tamayo-Velasco, Álvaro Peñarrubia Ponce, María Jesús Álvarez, Francisco Javier Gonzalo-Benito, Hugo de la Fuente, Ignacio Pérez-González, Sonia Rico, Lucía Jiménez García, María Teresa Sánchez Rodríguez, Alba Hijas Villaizan, Milagros Martín-Fernández, Marta Dueñas, Carlos Gómez-Sánchez, Esther Heredia-Rodríguez, María Gorgojo-Galindo, Óscar Fernández, Itziar del Río, Lourdes Carnicero-Frutos, Irene Muñoz-Moreno, María Fe Tamayo, Eduardo Bernardo, David Martínez-Paz, Pedro |
author_sort | Tamayo-Velasco, Álvaro |
collection | PubMed |
description | Severe status of coronavirus disease 2019 (COVID-19) is extremely associated to cytokine release. Moreover, it has been suggested that blood group is also associated with the prevalence and severity of this disease. However, the relationship between the cytokine profile and blood group remains unclear in COVID-19 patients. In this sense, we prospectively recruited 108 COVID-19 patients between March and April 2020 and divided according to ABO blood group. For the analysis of 45 cytokines, plasma samples were collected in the time of admission to hospital ward or intensive care unit and at the sixth day after hospital admission. The results show that there was a risk of more than two times lower of mechanical ventilation or death in patients with blood group O (log rank: p = 0.042). At first time, all statistically significant cytokine levels, except from hepatocyte growth factor, were higher in O blood group patients meanwhile the second time showed a significant drop, between 20% and 40%. In contrast, A/B/AB group presented a maintenance of cytokine levels during time. Hepatocyte growth factor showed a significant association with intubation or mortality risk in non-O blood group patients (OR: 4.229, 95% CI (2.064–8.665), p < 0.001) and also was the only one bad prognosis biomarker in O blood group patients (OR: 8.852, 95% CI (1.540–50.878), p = 0.015). Therefore, higher cytokine levels in O blood group are associated with a better outcome than A/B/AB group in COVID-19 patients. |
format | Online Article Text |
id | pubmed-8548690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85486902021-10-28 Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can Tamayo-Velasco, Álvaro Peñarrubia Ponce, María Jesús Álvarez, Francisco Javier Gonzalo-Benito, Hugo de la Fuente, Ignacio Pérez-González, Sonia Rico, Lucía Jiménez García, María Teresa Sánchez Rodríguez, Alba Hijas Villaizan, Milagros Martín-Fernández, Marta Dueñas, Carlos Gómez-Sánchez, Esther Heredia-Rodríguez, María Gorgojo-Galindo, Óscar Fernández, Itziar del Río, Lourdes Carnicero-Frutos, Irene Muñoz-Moreno, María Fe Tamayo, Eduardo Bernardo, David Martínez-Paz, Pedro Front Immunol Immunology Severe status of coronavirus disease 2019 (COVID-19) is extremely associated to cytokine release. Moreover, it has been suggested that blood group is also associated with the prevalence and severity of this disease. However, the relationship between the cytokine profile and blood group remains unclear in COVID-19 patients. In this sense, we prospectively recruited 108 COVID-19 patients between March and April 2020 and divided according to ABO blood group. For the analysis of 45 cytokines, plasma samples were collected in the time of admission to hospital ward or intensive care unit and at the sixth day after hospital admission. The results show that there was a risk of more than two times lower of mechanical ventilation or death in patients with blood group O (log rank: p = 0.042). At first time, all statistically significant cytokine levels, except from hepatocyte growth factor, were higher in O blood group patients meanwhile the second time showed a significant drop, between 20% and 40%. In contrast, A/B/AB group presented a maintenance of cytokine levels during time. Hepatocyte growth factor showed a significant association with intubation or mortality risk in non-O blood group patients (OR: 4.229, 95% CI (2.064–8.665), p < 0.001) and also was the only one bad prognosis biomarker in O blood group patients (OR: 8.852, 95% CI (1.540–50.878), p = 0.015). Therefore, higher cytokine levels in O blood group are associated with a better outcome than A/B/AB group in COVID-19 patients. Frontiers Media S.A. 2021-10-13 /pmc/articles/PMC8548690/ /pubmed/34721388 http://dx.doi.org/10.3389/fimmu.2021.726283 Text en Copyright © 2021 Tamayo-Velasco, Peñarrubia Ponce, Álvarez, Gonzalo-Benito, de la Fuente, Pérez-González, Rico, Jiménez García, Sánchez Rodríguez, Hijas Villaizan, Martín-Fernández, Dueñas, Gómez-Sánchez, Heredia-Rodríguez, Gorgojo-Galindo, Fernández, del Río, Carnicero-Frutos, Muñoz-Moreno, Tamayo, Bernardo and Martínez-Paz https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Tamayo-Velasco, Álvaro Peñarrubia Ponce, María Jesús Álvarez, Francisco Javier Gonzalo-Benito, Hugo de la Fuente, Ignacio Pérez-González, Sonia Rico, Lucía Jiménez García, María Teresa Sánchez Rodríguez, Alba Hijas Villaizan, Milagros Martín-Fernández, Marta Dueñas, Carlos Gómez-Sánchez, Esther Heredia-Rodríguez, María Gorgojo-Galindo, Óscar Fernández, Itziar del Río, Lourdes Carnicero-Frutos, Irene Muñoz-Moreno, María Fe Tamayo, Eduardo Bernardo, David Martínez-Paz, Pedro Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can |
title | Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can |
title_full | Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can |
title_fullStr | Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can |
title_full_unstemmed | Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can |
title_short | Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can |
title_sort | can the cytokine profile according to abo blood groups be related to worse outcome in covid-19 patients? yes, they can |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548690/ https://www.ncbi.nlm.nih.gov/pubmed/34721388 http://dx.doi.org/10.3389/fimmu.2021.726283 |
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