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Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can

Severe status of coronavirus disease 2019 (COVID-19) is extremely associated to cytokine release. Moreover, it has been suggested that blood group is also associated with the prevalence and severity of this disease. However, the relationship between the cytokine profile and blood group remains uncle...

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Autores principales: Tamayo-Velasco, Álvaro, Peñarrubia Ponce, María Jesús, Álvarez, Francisco Javier, Gonzalo-Benito, Hugo, de la Fuente, Ignacio, Pérez-González, Sonia, Rico, Lucía, Jiménez García, María Teresa, Sánchez Rodríguez, Alba, Hijas Villaizan, Milagros, Martín-Fernández, Marta, Dueñas, Carlos, Gómez-Sánchez, Esther, Heredia-Rodríguez, María, Gorgojo-Galindo, Óscar, Fernández, Itziar, del Río, Lourdes, Carnicero-Frutos, Irene, Muñoz-Moreno, María Fe, Tamayo, Eduardo, Bernardo, David, Martínez-Paz, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548690/
https://www.ncbi.nlm.nih.gov/pubmed/34721388
http://dx.doi.org/10.3389/fimmu.2021.726283
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author Tamayo-Velasco, Álvaro
Peñarrubia Ponce, María Jesús
Álvarez, Francisco Javier
Gonzalo-Benito, Hugo
de la Fuente, Ignacio
Pérez-González, Sonia
Rico, Lucía
Jiménez García, María Teresa
Sánchez Rodríguez, Alba
Hijas Villaizan, Milagros
Martín-Fernández, Marta
Dueñas, Carlos
Gómez-Sánchez, Esther
Heredia-Rodríguez, María
Gorgojo-Galindo, Óscar
Fernández, Itziar
del Río, Lourdes
Carnicero-Frutos, Irene
Muñoz-Moreno, María Fe
Tamayo, Eduardo
Bernardo, David
Martínez-Paz, Pedro
author_facet Tamayo-Velasco, Álvaro
Peñarrubia Ponce, María Jesús
Álvarez, Francisco Javier
Gonzalo-Benito, Hugo
de la Fuente, Ignacio
Pérez-González, Sonia
Rico, Lucía
Jiménez García, María Teresa
Sánchez Rodríguez, Alba
Hijas Villaizan, Milagros
Martín-Fernández, Marta
Dueñas, Carlos
Gómez-Sánchez, Esther
Heredia-Rodríguez, María
Gorgojo-Galindo, Óscar
Fernández, Itziar
del Río, Lourdes
Carnicero-Frutos, Irene
Muñoz-Moreno, María Fe
Tamayo, Eduardo
Bernardo, David
Martínez-Paz, Pedro
author_sort Tamayo-Velasco, Álvaro
collection PubMed
description Severe status of coronavirus disease 2019 (COVID-19) is extremely associated to cytokine release. Moreover, it has been suggested that blood group is also associated with the prevalence and severity of this disease. However, the relationship between the cytokine profile and blood group remains unclear in COVID-19 patients. In this sense, we prospectively recruited 108 COVID-19 patients between March and April 2020 and divided according to ABO blood group. For the analysis of 45 cytokines, plasma samples were collected in the time of admission to hospital ward or intensive care unit and at the sixth day after hospital admission. The results show that there was a risk of more than two times lower of mechanical ventilation or death in patients with blood group O (log rank: p = 0.042). At first time, all statistically significant cytokine levels, except from hepatocyte growth factor, were higher in O blood group patients meanwhile the second time showed a significant drop, between 20% and 40%. In contrast, A/B/AB group presented a maintenance of cytokine levels during time. Hepatocyte growth factor showed a significant association with intubation or mortality risk in non-O blood group patients (OR: 4.229, 95% CI (2.064–8.665), p < 0.001) and also was the only one bad prognosis biomarker in O blood group patients (OR: 8.852, 95% CI (1.540–50.878), p = 0.015). Therefore, higher cytokine levels in O blood group are associated with a better outcome than A/B/AB group in COVID-19 patients.
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spelling pubmed-85486902021-10-28 Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can Tamayo-Velasco, Álvaro Peñarrubia Ponce, María Jesús Álvarez, Francisco Javier Gonzalo-Benito, Hugo de la Fuente, Ignacio Pérez-González, Sonia Rico, Lucía Jiménez García, María Teresa Sánchez Rodríguez, Alba Hijas Villaizan, Milagros Martín-Fernández, Marta Dueñas, Carlos Gómez-Sánchez, Esther Heredia-Rodríguez, María Gorgojo-Galindo, Óscar Fernández, Itziar del Río, Lourdes Carnicero-Frutos, Irene Muñoz-Moreno, María Fe Tamayo, Eduardo Bernardo, David Martínez-Paz, Pedro Front Immunol Immunology Severe status of coronavirus disease 2019 (COVID-19) is extremely associated to cytokine release. Moreover, it has been suggested that blood group is also associated with the prevalence and severity of this disease. However, the relationship between the cytokine profile and blood group remains unclear in COVID-19 patients. In this sense, we prospectively recruited 108 COVID-19 patients between March and April 2020 and divided according to ABO blood group. For the analysis of 45 cytokines, plasma samples were collected in the time of admission to hospital ward or intensive care unit and at the sixth day after hospital admission. The results show that there was a risk of more than two times lower of mechanical ventilation or death in patients with blood group O (log rank: p = 0.042). At first time, all statistically significant cytokine levels, except from hepatocyte growth factor, were higher in O blood group patients meanwhile the second time showed a significant drop, between 20% and 40%. In contrast, A/B/AB group presented a maintenance of cytokine levels during time. Hepatocyte growth factor showed a significant association with intubation or mortality risk in non-O blood group patients (OR: 4.229, 95% CI (2.064–8.665), p < 0.001) and also was the only one bad prognosis biomarker in O blood group patients (OR: 8.852, 95% CI (1.540–50.878), p = 0.015). Therefore, higher cytokine levels in O blood group are associated with a better outcome than A/B/AB group in COVID-19 patients. Frontiers Media S.A. 2021-10-13 /pmc/articles/PMC8548690/ /pubmed/34721388 http://dx.doi.org/10.3389/fimmu.2021.726283 Text en Copyright © 2021 Tamayo-Velasco, Peñarrubia Ponce, Álvarez, Gonzalo-Benito, de la Fuente, Pérez-González, Rico, Jiménez García, Sánchez Rodríguez, Hijas Villaizan, Martín-Fernández, Dueñas, Gómez-Sánchez, Heredia-Rodríguez, Gorgojo-Galindo, Fernández, del Río, Carnicero-Frutos, Muñoz-Moreno, Tamayo, Bernardo and Martínez-Paz https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Tamayo-Velasco, Álvaro
Peñarrubia Ponce, María Jesús
Álvarez, Francisco Javier
Gonzalo-Benito, Hugo
de la Fuente, Ignacio
Pérez-González, Sonia
Rico, Lucía
Jiménez García, María Teresa
Sánchez Rodríguez, Alba
Hijas Villaizan, Milagros
Martín-Fernández, Marta
Dueñas, Carlos
Gómez-Sánchez, Esther
Heredia-Rodríguez, María
Gorgojo-Galindo, Óscar
Fernández, Itziar
del Río, Lourdes
Carnicero-Frutos, Irene
Muñoz-Moreno, María Fe
Tamayo, Eduardo
Bernardo, David
Martínez-Paz, Pedro
Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can
title Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can
title_full Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can
title_fullStr Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can
title_full_unstemmed Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can
title_short Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can
title_sort can the cytokine profile according to abo blood groups be related to worse outcome in covid-19 patients? yes, they can
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548690/
https://www.ncbi.nlm.nih.gov/pubmed/34721388
http://dx.doi.org/10.3389/fimmu.2021.726283
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