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Magnetoencephalography STOUT Method Adapted to Radiofrequency Thermocoagulation for MR-Negative Insular Epilepsy: A Case Report

Epilepsy is one of the most challenging neurologic diseases confronted by human society. Approximately 30–40% of the worldwide epilepsy patients are diagnosed with drug-resistant epilepsy and require pre-surgery evaluation. Magnetoencephalography (MEG) is a unique technology that provides optimal sp...

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Autores principales: Ma, Kaiqiang, Luan, Guoming, Wang, Xiongfei, Luo, Shen, Qin, Lang, Teng, Pengfei, Guan, Yuguang, Zhao, Meng, Wang, Jing, Wang, Mengyang, Gao, Jia-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548742/
https://www.ncbi.nlm.nih.gov/pubmed/34721253
http://dx.doi.org/10.3389/fneur.2021.683299
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author Ma, Kaiqiang
Luan, Guoming
Wang, Xiongfei
Luo, Shen
Qin, Lang
Teng, Pengfei
Guan, Yuguang
Zhao, Meng
Wang, Jing
Wang, Mengyang
Gao, Jia-Hong
author_facet Ma, Kaiqiang
Luan, Guoming
Wang, Xiongfei
Luo, Shen
Qin, Lang
Teng, Pengfei
Guan, Yuguang
Zhao, Meng
Wang, Jing
Wang, Mengyang
Gao, Jia-Hong
author_sort Ma, Kaiqiang
collection PubMed
description Epilepsy is one of the most challenging neurologic diseases confronted by human society. Approximately 30–40% of the worldwide epilepsy patients are diagnosed with drug-resistant epilepsy and require pre-surgery evaluation. Magnetoencephalography (MEG) is a unique technology that provides optimal spatial-temporal resolution and has become a powerful non-invasive imaging modality that can localize the interictal spikes and guide the implantation of intracranial electrodes. Currently, the most widely used MEG source estimation method for clinical applications is equivalent current dipoles (ECD). However, ECD has difficulties in precisely locating deep sources such as insular lobe. In contrast to ECD, another MEG source estimation method named spatio-temporal unifying tomography (STOUT) with spatial sparsity has particular advantages in locating deep sources. In this case study, we recruited a 5 year-old female patient with insular lobe epilepsy and her seizure recurred in 1 year after receiving the radiofrequency thermocoagulation (RF-TC) therapy. The STOUT method was adopted to locate deep sources for identifying the epileptic foci in epilepsy evaluation. MEG STOUT method strongly supported a stereo-electroencephalographic (SEEG)-guided RF-TC operation, and the patient reported a satisfactory therapeutic effect. This case raises the possibility that STOUT method can be used particularly for the localization of deep sources, and successfully conducted RF-TC under the guidance of MEG STOUT results.
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spelling pubmed-85487422021-10-28 Magnetoencephalography STOUT Method Adapted to Radiofrequency Thermocoagulation for MR-Negative Insular Epilepsy: A Case Report Ma, Kaiqiang Luan, Guoming Wang, Xiongfei Luo, Shen Qin, Lang Teng, Pengfei Guan, Yuguang Zhao, Meng Wang, Jing Wang, Mengyang Gao, Jia-Hong Front Neurol Neurology Epilepsy is one of the most challenging neurologic diseases confronted by human society. Approximately 30–40% of the worldwide epilepsy patients are diagnosed with drug-resistant epilepsy and require pre-surgery evaluation. Magnetoencephalography (MEG) is a unique technology that provides optimal spatial-temporal resolution and has become a powerful non-invasive imaging modality that can localize the interictal spikes and guide the implantation of intracranial electrodes. Currently, the most widely used MEG source estimation method for clinical applications is equivalent current dipoles (ECD). However, ECD has difficulties in precisely locating deep sources such as insular lobe. In contrast to ECD, another MEG source estimation method named spatio-temporal unifying tomography (STOUT) with spatial sparsity has particular advantages in locating deep sources. In this case study, we recruited a 5 year-old female patient with insular lobe epilepsy and her seizure recurred in 1 year after receiving the radiofrequency thermocoagulation (RF-TC) therapy. The STOUT method was adopted to locate deep sources for identifying the epileptic foci in epilepsy evaluation. MEG STOUT method strongly supported a stereo-electroencephalographic (SEEG)-guided RF-TC operation, and the patient reported a satisfactory therapeutic effect. This case raises the possibility that STOUT method can be used particularly for the localization of deep sources, and successfully conducted RF-TC under the guidance of MEG STOUT results. Frontiers Media S.A. 2021-10-13 /pmc/articles/PMC8548742/ /pubmed/34721253 http://dx.doi.org/10.3389/fneur.2021.683299 Text en Copyright © 2021 Ma, Luan, Wang, Luo, Qin, Teng, Guan, Zhao, Wang, Wang and Gao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Ma, Kaiqiang
Luan, Guoming
Wang, Xiongfei
Luo, Shen
Qin, Lang
Teng, Pengfei
Guan, Yuguang
Zhao, Meng
Wang, Jing
Wang, Mengyang
Gao, Jia-Hong
Magnetoencephalography STOUT Method Adapted to Radiofrequency Thermocoagulation for MR-Negative Insular Epilepsy: A Case Report
title Magnetoencephalography STOUT Method Adapted to Radiofrequency Thermocoagulation for MR-Negative Insular Epilepsy: A Case Report
title_full Magnetoencephalography STOUT Method Adapted to Radiofrequency Thermocoagulation for MR-Negative Insular Epilepsy: A Case Report
title_fullStr Magnetoencephalography STOUT Method Adapted to Radiofrequency Thermocoagulation for MR-Negative Insular Epilepsy: A Case Report
title_full_unstemmed Magnetoencephalography STOUT Method Adapted to Radiofrequency Thermocoagulation for MR-Negative Insular Epilepsy: A Case Report
title_short Magnetoencephalography STOUT Method Adapted to Radiofrequency Thermocoagulation for MR-Negative Insular Epilepsy: A Case Report
title_sort magnetoencephalography stout method adapted to radiofrequency thermocoagulation for mr-negative insular epilepsy: a case report
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548742/
https://www.ncbi.nlm.nih.gov/pubmed/34721253
http://dx.doi.org/10.3389/fneur.2021.683299
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