APOL1 variants contribute to racial disparity in sepsis

Genetic variants in apolipoprotein L1 (APOL1) — present only in individuals of African ancestry — contribute to increased susceptibility to sepsis and COVID-19. APOL1 variants impair mitophagy in endothelial cells, allowing the release of mitochondrial DNA that activates inflammasome and nucleotide...

Descripción completa

Detalles Bibliográficos
Autor principal: Bird, Lucy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548855/
https://www.ncbi.nlm.nih.gov/pubmed/34707254
http://dx.doi.org/10.1038/s41577-021-00647-3
Descripción
Sumario:Genetic variants in apolipoprotein L1 (APOL1) — present only in individuals of African ancestry — contribute to increased susceptibility to sepsis and COVID-19. APOL1 variants impair mitophagy in endothelial cells, allowing the release of mitochondrial DNA that activates inflammasome and nucleotide sensing pathways.

Ejemplares similares