APOL1 variants contribute to racial disparity in sepsis

Genetic variants in apolipoprotein L1 (APOL1) — present only in individuals of African ancestry — contribute to increased susceptibility to sepsis and COVID-19. APOL1 variants impair mitophagy in endothelial cells, allowing the release of mitochondrial DNA that activates inflammasome and nucleotide...

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Detalles Bibliográficos
Autor principal: Bird, Lucy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548855/
https://www.ncbi.nlm.nih.gov/pubmed/34707254
http://dx.doi.org/10.1038/s41577-021-00647-3
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author Bird, Lucy
author_facet Bird, Lucy
author_sort Bird, Lucy
collection PubMed
description Genetic variants in apolipoprotein L1 (APOL1) — present only in individuals of African ancestry — contribute to increased susceptibility to sepsis and COVID-19. APOL1 variants impair mitophagy in endothelial cells, allowing the release of mitochondrial DNA that activates inflammasome and nucleotide sensing pathways.
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spelling pubmed-85488552021-10-27 APOL1 variants contribute to racial disparity in sepsis Bird, Lucy Nat Rev Immunol Research Highlight Genetic variants in apolipoprotein L1 (APOL1) — present only in individuals of African ancestry — contribute to increased susceptibility to sepsis and COVID-19. APOL1 variants impair mitophagy in endothelial cells, allowing the release of mitochondrial DNA that activates inflammasome and nucleotide sensing pathways. Nature Publishing Group UK 2021-10-27 2021 /pmc/articles/PMC8548855/ /pubmed/34707254 http://dx.doi.org/10.1038/s41577-021-00647-3 Text en © Springer Nature Limited 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Research Highlight
Bird, Lucy
APOL1 variants contribute to racial disparity in sepsis
title APOL1 variants contribute to racial disparity in sepsis
title_full APOL1 variants contribute to racial disparity in sepsis
title_fullStr APOL1 variants contribute to racial disparity in sepsis
title_full_unstemmed APOL1 variants contribute to racial disparity in sepsis
title_short APOL1 variants contribute to racial disparity in sepsis
title_sort apol1 variants contribute to racial disparity in sepsis
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548855/
https://www.ncbi.nlm.nih.gov/pubmed/34707254
http://dx.doi.org/10.1038/s41577-021-00647-3
work_keys_str_mv AT birdlucy apol1variantscontributetoracialdisparityinsepsis

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