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APOL1 variants contribute to racial disparity in sepsis

Genetic variants in apolipoprotein L1 (APOL1) — present only in individuals of African ancestry — contribute to increased susceptibility to sepsis and COVID-19. APOL1 variants impair mitophagy in endothelial cells, allowing the release of mitochondrial DNA that activates inflammasome and nucleotide...

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Detalles Bibliográficos
Autor principal:	Bird, Lucy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Research Highlight
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548855/ https://www.ncbi.nlm.nih.gov/pubmed/34707254 http://dx.doi.org/10.1038/s41577-021-00647-3

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