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Melioidosis in Bihar, India: unearthing the first of many?

Melioidosis, a disease with protean clinical manifestations, is prevalent in many parts of India, with established endemic hotspots on the southern coast of the country. However, it is still underdiagnosed in many resource-poor regions of the country. We report what is, to the best of our knowledge,...

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Autores principales: Halim, Isra, Kokkayil, Prathyusha, Kirti, Ravi, Priyadarshi, Rajeev Nayan, Sarfraz, Asim, Pati, Binod Kumar, Thakuria, Bhaskar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549391/
https://www.ncbi.nlm.nih.gov/pubmed/34712905
http://dx.doi.org/10.1099/acmi.0.000260
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author Halim, Isra
Kokkayil, Prathyusha
Kirti, Ravi
Priyadarshi, Rajeev Nayan
Sarfraz, Asim
Pati, Binod Kumar
Thakuria, Bhaskar
author_facet Halim, Isra
Kokkayil, Prathyusha
Kirti, Ravi
Priyadarshi, Rajeev Nayan
Sarfraz, Asim
Pati, Binod Kumar
Thakuria, Bhaskar
author_sort Halim, Isra
collection PubMed
description Melioidosis, a disease with protean clinical manifestations, is prevalent in many parts of India, with established endemic hotspots on the southern coast of the country. However, it is still underdiagnosed in many resource-poor regions of the country. We report what is, to the best of our knowledge, the first case of melioidosis diagnosed and treated in Bihar, an economically underdeveloped state in East India. The patient, a 52-year-old diabetic male, presented to the outpatient department with a fever of insidious onset along with pain and restriction of movement in the right shoulder joint and right knee joint, and swelling and tenderness of bilateral ankle joints. Radiological features were suggestive of multiple joint and organ abscesses. A diagnosis of disseminated septicaemic melioidosis was confirmed microbiologically. The patient improved clinically following aggressive treatment with meropenem and cotrimoxazole. The case highlights the need for increased clinical suspicion of melioidosis and adequate diagnostic facilities, as well as the need for early institution of appropriate empirical antibiotics in suspected cases of melioidosis in this region of the world.
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spelling pubmed-85493912021-10-27 Melioidosis in Bihar, India: unearthing the first of many? Halim, Isra Kokkayil, Prathyusha Kirti, Ravi Priyadarshi, Rajeev Nayan Sarfraz, Asim Pati, Binod Kumar Thakuria, Bhaskar Access Microbiol Case Reports Melioidosis, a disease with protean clinical manifestations, is prevalent in many parts of India, with established endemic hotspots on the southern coast of the country. However, it is still underdiagnosed in many resource-poor regions of the country. We report what is, to the best of our knowledge, the first case of melioidosis diagnosed and treated in Bihar, an economically underdeveloped state in East India. The patient, a 52-year-old diabetic male, presented to the outpatient department with a fever of insidious onset along with pain and restriction of movement in the right shoulder joint and right knee joint, and swelling and tenderness of bilateral ankle joints. Radiological features were suggestive of multiple joint and organ abscesses. A diagnosis of disseminated septicaemic melioidosis was confirmed microbiologically. The patient improved clinically following aggressive treatment with meropenem and cotrimoxazole. The case highlights the need for increased clinical suspicion of melioidosis and adequate diagnostic facilities, as well as the need for early institution of appropriate empirical antibiotics in suspected cases of melioidosis in this region of the world. Microbiology Society 2021-09-14 /pmc/articles/PMC8549391/ /pubmed/34712905 http://dx.doi.org/10.1099/acmi.0.000260 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article.
spellingShingle Case Reports
Halim, Isra
Kokkayil, Prathyusha
Kirti, Ravi
Priyadarshi, Rajeev Nayan
Sarfraz, Asim
Pati, Binod Kumar
Thakuria, Bhaskar
Melioidosis in Bihar, India: unearthing the first of many?
title Melioidosis in Bihar, India: unearthing the first of many?
title_full Melioidosis in Bihar, India: unearthing the first of many?
title_fullStr Melioidosis in Bihar, India: unearthing the first of many?
title_full_unstemmed Melioidosis in Bihar, India: unearthing the first of many?
title_short Melioidosis in Bihar, India: unearthing the first of many?
title_sort melioidosis in bihar, india: unearthing the first of many?
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549391/
https://www.ncbi.nlm.nih.gov/pubmed/34712905
http://dx.doi.org/10.1099/acmi.0.000260
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