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MOG antibody-associated encephalitis secondary to Covid-19: case report
BACKGROUND: While Covid-19 predominantly affects the respiratory system, neurological manifestations including encephalitis occur in some patients, possibly affecting the course and outcome of the disease. Here, we describe a unique case of a young man with Covid-19 and transient MOG-positive enceph...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549422/ https://www.ncbi.nlm.nih.gov/pubmed/34706651 http://dx.doi.org/10.1186/s12883-021-02449-5 |
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author | Durovic, Ervin Bien, Corinna Bien, Christian G. Isenmann, Stefan |
author_facet | Durovic, Ervin Bien, Corinna Bien, Christian G. Isenmann, Stefan |
author_sort | Durovic, Ervin |
collection | PubMed |
description | BACKGROUND: While Covid-19 predominantly affects the respiratory system, neurological manifestations including encephalitis occur in some patients, possibly affecting the course and outcome of the disease. Here, we describe a unique case of a young man with Covid-19 and transient MOG-positive encephalitis, with a benign course. CASE PRESENTATION: A 22-year-old male, with PCR confirmed Covid-19 infection was admitted because of persistent headache. The clinical examination was normal. Neuropsychological testing revealed distinct executive deficits. Brain MRI and cerebrospinal fluid (CSF) analysis were suggestive for encephalitis. Further laboratory examination revealed a serum MOG antibody titre. The headache improved with analgetic treatment and i.v. methylprednisolone. Consequently, the MOG antibody titer decreased and MRI lesions were resolving. The patient made a full recovery, with no signs of deterioration over the following months. CONCLUSIONS: Covid-19 manifestations in the CNS include encephalitis with variable course and prognosis. This case highlights a possible association between inflammation due to COVID-19 and transient secondary autoimmunity with transient MOG antibodies and atypical clinical presentation. |
format | Online Article Text |
id | pubmed-8549422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-85494222021-10-27 MOG antibody-associated encephalitis secondary to Covid-19: case report Durovic, Ervin Bien, Corinna Bien, Christian G. Isenmann, Stefan BMC Neurol Case Report BACKGROUND: While Covid-19 predominantly affects the respiratory system, neurological manifestations including encephalitis occur in some patients, possibly affecting the course and outcome of the disease. Here, we describe a unique case of a young man with Covid-19 and transient MOG-positive encephalitis, with a benign course. CASE PRESENTATION: A 22-year-old male, with PCR confirmed Covid-19 infection was admitted because of persistent headache. The clinical examination was normal. Neuropsychological testing revealed distinct executive deficits. Brain MRI and cerebrospinal fluid (CSF) analysis were suggestive for encephalitis. Further laboratory examination revealed a serum MOG antibody titre. The headache improved with analgetic treatment and i.v. methylprednisolone. Consequently, the MOG antibody titer decreased and MRI lesions were resolving. The patient made a full recovery, with no signs of deterioration over the following months. CONCLUSIONS: Covid-19 manifestations in the CNS include encephalitis with variable course and prognosis. This case highlights a possible association between inflammation due to COVID-19 and transient secondary autoimmunity with transient MOG antibodies and atypical clinical presentation. BioMed Central 2021-10-27 /pmc/articles/PMC8549422/ /pubmed/34706651 http://dx.doi.org/10.1186/s12883-021-02449-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Durovic, Ervin Bien, Corinna Bien, Christian G. Isenmann, Stefan MOG antibody-associated encephalitis secondary to Covid-19: case report |
title | MOG antibody-associated encephalitis secondary to Covid-19: case report |
title_full | MOG antibody-associated encephalitis secondary to Covid-19: case report |
title_fullStr | MOG antibody-associated encephalitis secondary to Covid-19: case report |
title_full_unstemmed | MOG antibody-associated encephalitis secondary to Covid-19: case report |
title_short | MOG antibody-associated encephalitis secondary to Covid-19: case report |
title_sort | mog antibody-associated encephalitis secondary to covid-19: case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549422/ https://www.ncbi.nlm.nih.gov/pubmed/34706651 http://dx.doi.org/10.1186/s12883-021-02449-5 |
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