Targeting Cbx3/HP1γ Induces LEF-1 and IL-21R to Promote Tumor-Infiltrating CD8 T-Cell Persistence

Immune checkpoint blockade (ICB) relieves CD8(+) T-cell exhaustion in most mutated tumors, and TCF-1 is implicated in converting progenitor exhausted cells to functional effector cells. However, identifying mechanisms that can prevent functional senescence and potentiate CD8(+) T-cell persistence fo...

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Detalles Bibliográficos
Autores principales: Le, Phuong T., Ha, Ngoc, Tran, Ngan K., Newman, Andrew G., Esselen, Katharine M., Dalrymple, John L., Schmelz, Eva M., Bhandoola, Avinash, Xue, Hai-Hui, Singh, Prim B., Thai, To-Ha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549513/
https://www.ncbi.nlm.nih.gov/pubmed/34721405
http://dx.doi.org/10.3389/fimmu.2021.738958

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