Cosmc transfection decreases malignant behavior of Tn(+) cells and enhances sensitivity to apoptosis when induced by Apo2L/TRAIL via alteration of O-glycan structure

Cosmc mutations may cause abnormal O-glycosylation and result in Tn antigen expression. In the current study, it was discovered that proliferation and migration of Tn+ cells (Jurkat T and LS174T-Tn(+) cells) with mutant Cosmc decreased after transfected Cosmc, and their sensitivity to apoptosis indu...

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Detalles Bibliográficos
Autores principales: Ding, Ruisong, Hu, Xingyou, Hu, Wen, Du, Zhenzhen, Huang, Panpan, Wang, Mengyang, Sheng, Jiaoyue, Ma, Yanchao, Wang, Ailing, Luan, Xiying, Dong, Menghua, Cao, Qizhi, Zou, Yanfen, Hu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549606/
https://www.ncbi.nlm.nih.gov/pubmed/34644263
http://dx.doi.org/10.18632/aging.203633

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