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Recent Strategies to Combat Infections from Biofilm-Forming Bacteria on Orthopaedic Implants
Biofilm-related implant infections (BRII) are a disastrous complication of both elective and trauma orthopaedic surgery and occur when an implant becomes colonised by bacteria. The definitive treatment to eradicate the infections once a biofilm has established is surgical excision of the implant and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549706/ https://www.ncbi.nlm.nih.gov/pubmed/34638591 http://dx.doi.org/10.3390/ijms221910243 |
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author | Rodríguez-Merchán, Emérito Carlos Davidson, Donald J. Liddle, Alexander D. |
author_facet | Rodríguez-Merchán, Emérito Carlos Davidson, Donald J. Liddle, Alexander D. |
author_sort | Rodríguez-Merchán, Emérito Carlos |
collection | PubMed |
description | Biofilm-related implant infections (BRII) are a disastrous complication of both elective and trauma orthopaedic surgery and occur when an implant becomes colonised by bacteria. The definitive treatment to eradicate the infections once a biofilm has established is surgical excision of the implant and thorough local debridement, but this carries a significant socioeconomic cost, the outcomes for the patient are often poor, and there is a significant risk of recurrence. Due to the large volumes of surgical procedures performed annually involving medical device implantation, both in orthopaedic surgery and healthcare in general, and with the incidence of implant-related infection being as high as 5%, interventions to prevent and treat BRII are a major focus of research. As such, innovation is progressing at a very fast pace; the aim of this study is to review the latest interventions for the prevention and treatment of BRII, with a particular focus on implant-related approaches. |
format | Online Article Text |
id | pubmed-8549706 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85497062021-10-28 Recent Strategies to Combat Infections from Biofilm-Forming Bacteria on Orthopaedic Implants Rodríguez-Merchán, Emérito Carlos Davidson, Donald J. Liddle, Alexander D. Int J Mol Sci Review Biofilm-related implant infections (BRII) are a disastrous complication of both elective and trauma orthopaedic surgery and occur when an implant becomes colonised by bacteria. The definitive treatment to eradicate the infections once a biofilm has established is surgical excision of the implant and thorough local debridement, but this carries a significant socioeconomic cost, the outcomes for the patient are often poor, and there is a significant risk of recurrence. Due to the large volumes of surgical procedures performed annually involving medical device implantation, both in orthopaedic surgery and healthcare in general, and with the incidence of implant-related infection being as high as 5%, interventions to prevent and treat BRII are a major focus of research. As such, innovation is progressing at a very fast pace; the aim of this study is to review the latest interventions for the prevention and treatment of BRII, with a particular focus on implant-related approaches. MDPI 2021-09-23 /pmc/articles/PMC8549706/ /pubmed/34638591 http://dx.doi.org/10.3390/ijms221910243 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rodríguez-Merchán, Emérito Carlos Davidson, Donald J. Liddle, Alexander D. Recent Strategies to Combat Infections from Biofilm-Forming Bacteria on Orthopaedic Implants |
title | Recent Strategies to Combat Infections from Biofilm-Forming Bacteria on Orthopaedic Implants |
title_full | Recent Strategies to Combat Infections from Biofilm-Forming Bacteria on Orthopaedic Implants |
title_fullStr | Recent Strategies to Combat Infections from Biofilm-Forming Bacteria on Orthopaedic Implants |
title_full_unstemmed | Recent Strategies to Combat Infections from Biofilm-Forming Bacteria on Orthopaedic Implants |
title_short | Recent Strategies to Combat Infections from Biofilm-Forming Bacteria on Orthopaedic Implants |
title_sort | recent strategies to combat infections from biofilm-forming bacteria on orthopaedic implants |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549706/ https://www.ncbi.nlm.nih.gov/pubmed/34638591 http://dx.doi.org/10.3390/ijms221910243 |
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