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The Application of CRISPR/Cas Systems for Antiviral Therapy
As CRISPR/Cas systems have been refined over time, there has been an effort to apply them to real world problems, such as developing sequence-targeted antiviral therapies. Viruses pose a major threat to humans and new tools are urgently needed to combat these rapidly mutating pathogens. Importantly,...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549726/ https://www.ncbi.nlm.nih.gov/pubmed/34723245 http://dx.doi.org/10.3389/fgeed.2021.745559 |
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author | Baddeley, Helen J. E. Isalan, Mark |
author_facet | Baddeley, Helen J. E. Isalan, Mark |
author_sort | Baddeley, Helen J. E. |
collection | PubMed |
description | As CRISPR/Cas systems have been refined over time, there has been an effort to apply them to real world problems, such as developing sequence-targeted antiviral therapies. Viruses pose a major threat to humans and new tools are urgently needed to combat these rapidly mutating pathogens. Importantly, a variety of CRISPR systems have the potential to directly cleave DNA and RNA viral genomes, in a targeted and easily-adaptable manner, thus preventing or treating infections. This perspective article highlights recent studies using different Cas effectors against various RNA viruses causing acute infections in humans; a latent virus (HIV-1); a chronic virus (hepatitis B); and viruses infecting livestock and animal species of industrial importance. The outlook and remaining challenges are discussed, particularly in the context of tacking newly emerging viruses, such as SARS-CoV-2. |
format | Online Article Text |
id | pubmed-8549726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85497262021-10-29 The Application of CRISPR/Cas Systems for Antiviral Therapy Baddeley, Helen J. E. Isalan, Mark Front Genome Ed Genome Editing As CRISPR/Cas systems have been refined over time, there has been an effort to apply them to real world problems, such as developing sequence-targeted antiviral therapies. Viruses pose a major threat to humans and new tools are urgently needed to combat these rapidly mutating pathogens. Importantly, a variety of CRISPR systems have the potential to directly cleave DNA and RNA viral genomes, in a targeted and easily-adaptable manner, thus preventing or treating infections. This perspective article highlights recent studies using different Cas effectors against various RNA viruses causing acute infections in humans; a latent virus (HIV-1); a chronic virus (hepatitis B); and viruses infecting livestock and animal species of industrial importance. The outlook and remaining challenges are discussed, particularly in the context of tacking newly emerging viruses, such as SARS-CoV-2. Frontiers Media S.A. 2021-10-13 /pmc/articles/PMC8549726/ /pubmed/34723245 http://dx.doi.org/10.3389/fgeed.2021.745559 Text en Copyright © 2021 Baddeley and Isalan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genome Editing Baddeley, Helen J. E. Isalan, Mark The Application of CRISPR/Cas Systems for Antiviral Therapy |
title | The Application of CRISPR/Cas Systems for Antiviral Therapy |
title_full | The Application of CRISPR/Cas Systems for Antiviral Therapy |
title_fullStr | The Application of CRISPR/Cas Systems for Antiviral Therapy |
title_full_unstemmed | The Application of CRISPR/Cas Systems for Antiviral Therapy |
title_short | The Application of CRISPR/Cas Systems for Antiviral Therapy |
title_sort | application of crispr/cas systems for antiviral therapy |
topic | Genome Editing |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549726/ https://www.ncbi.nlm.nih.gov/pubmed/34723245 http://dx.doi.org/10.3389/fgeed.2021.745559 |
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