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The risk of venous thromboembolism and physical activity level, especially high level: a systematic review

Venous thromboembolism (VTE) is the third most common cause of cardiovascular disease. Connection between high level of physical activity (PA) and the onset of VTE is unknown. We searched the literature on the possible association between PA level, especially high levels, and the risk of VTE. A syst...

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Autores principales: Danin-Mankowitz, H., Ugarph-Morawski, A., Braunschweig, F., Wändell, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550020/
https://www.ncbi.nlm.nih.gov/pubmed/33389612
http://dx.doi.org/10.1007/s11239-020-02372-5
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author Danin-Mankowitz, H.
Ugarph-Morawski, A.
Braunschweig, F.
Wändell, P.
author_facet Danin-Mankowitz, H.
Ugarph-Morawski, A.
Braunschweig, F.
Wändell, P.
author_sort Danin-Mankowitz, H.
collection PubMed
description Venous thromboembolism (VTE) is the third most common cause of cardiovascular disease. Connection between high level of physical activity (PA) and the onset of VTE is unknown. We searched the literature on the possible association between PA level, especially high levels, and the risk of VTE. A systematic review was carried out to identify relevant articles on the relation between PA level and VTE. The initial search was conducted together with the Karolinska Institutet University Library in February 2018, with follow-up searches after that. In total, 4383 records were found and then screened for exclusion of duplicates and articles outside the area of interest. In total, 16 articles with data on 3 or more levels of PA were included. Of these, 12 were cohort and 4 were case-control studies. Totally 13 studies aimed at investigating VTE cases primarily, while three studies had other primary outcomes. Of the 16 studies, five found a U-shaped association between PA level and VTE risk, although non-significant in three of them. Two articles described an association between a more intense physical activity and a higher risk of VTE, which was significant in one. Nine studies found associations between increasing PA levels and a decreasing VTE risk. Available literature provides diverging results as to the association between high levels of PA and the risk of venous thromboembolism, but with several studies showing an association. Further research is warranted to clarify the relationship between high level PA and VTE. SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s11239-020-02372-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-85500202021-10-29 The risk of venous thromboembolism and physical activity level, especially high level: a systematic review Danin-Mankowitz, H. Ugarph-Morawski, A. Braunschweig, F. Wändell, P. J Thromb Thrombolysis Article Venous thromboembolism (VTE) is the third most common cause of cardiovascular disease. Connection between high level of physical activity (PA) and the onset of VTE is unknown. We searched the literature on the possible association between PA level, especially high levels, and the risk of VTE. A systematic review was carried out to identify relevant articles on the relation between PA level and VTE. The initial search was conducted together with the Karolinska Institutet University Library in February 2018, with follow-up searches after that. In total, 4383 records were found and then screened for exclusion of duplicates and articles outside the area of interest. In total, 16 articles with data on 3 or more levels of PA were included. Of these, 12 were cohort and 4 were case-control studies. Totally 13 studies aimed at investigating VTE cases primarily, while three studies had other primary outcomes. Of the 16 studies, five found a U-shaped association between PA level and VTE risk, although non-significant in three of them. Two articles described an association between a more intense physical activity and a higher risk of VTE, which was significant in one. Nine studies found associations between increasing PA levels and a decreasing VTE risk. Available literature provides diverging results as to the association between high levels of PA and the risk of venous thromboembolism, but with several studies showing an association. Further research is warranted to clarify the relationship between high level PA and VTE. SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s11239-020-02372-5) contains supplementary material, which is available to authorized users. Springer US 2021-01-02 2021 /pmc/articles/PMC8550020/ /pubmed/33389612 http://dx.doi.org/10.1007/s11239-020-02372-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Danin-Mankowitz, H.
Ugarph-Morawski, A.
Braunschweig, F.
Wändell, P.
The risk of venous thromboembolism and physical activity level, especially high level: a systematic review
title The risk of venous thromboembolism and physical activity level, especially high level: a systematic review
title_full The risk of venous thromboembolism and physical activity level, especially high level: a systematic review
title_fullStr The risk of venous thromboembolism and physical activity level, especially high level: a systematic review
title_full_unstemmed The risk of venous thromboembolism and physical activity level, especially high level: a systematic review
title_short The risk of venous thromboembolism and physical activity level, especially high level: a systematic review
title_sort risk of venous thromboembolism and physical activity level, especially high level: a systematic review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550020/
https://www.ncbi.nlm.nih.gov/pubmed/33389612
http://dx.doi.org/10.1007/s11239-020-02372-5
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