Acute Endothelial Graft Rejection Following COVID-19 Infection

Here, we report a case of acute endothelial graft rejection following coronavirus disease 2019 (COVID-19). A 57-year-old woman who underwent therapeutic penetrating keratoplasty for a perforated infectious corneal ulcer in her right eye developed severe acute respiratory syndrome coronavirus 2 infec...

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Detalles Bibliográficos
Autores principales: Behera, Geeta, Gokhale, Tanmay, Babu, Krishna R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Ophthalmology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550024/
https://www.ncbi.nlm.nih.gov/pubmed/34722015
http://dx.doi.org/10.7759/cureus.19084
Descripción
Sumario:Here, we report a case of acute endothelial graft rejection following coronavirus disease 2019 (COVID-19). A 57-year-old woman who underwent therapeutic penetrating keratoplasty for a perforated infectious corneal ulcer in her right eye developed severe acute respiratory syndrome coronavirus 2 infection, which required intensive care and treatment with steroids. Acute endothelial graft rejection was seen at three weeks postoperatively and managed with high-dose corticosteroids. Despite standard therapy, secondary graft failure was observed. Immune dysregulation associated with COVID-19 may be a significant cause of acute endothelial graft rejection among keratoplasty patients with COVID-19.

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