Acute Endothelial Graft Rejection Following COVID-19 Infection

Here, we report a case of acute endothelial graft rejection following coronavirus disease 2019 (COVID-19). A 57-year-old woman who underwent therapeutic penetrating keratoplasty for a perforated infectious corneal ulcer in her right eye developed severe acute respiratory syndrome coronavirus 2 infec...

Descripción completa

Detalles Bibliográficos
Autores principales: Behera, Geeta, Gokhale, Tanmay, Babu, Krishna R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Ophthalmology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550024/
https://www.ncbi.nlm.nih.gov/pubmed/34722015
http://dx.doi.org/10.7759/cureus.19084
_version_ 1784590876122546176
author Behera, Geeta
Gokhale, Tanmay
Babu, Krishna R
author_facet Behera, Geeta
Gokhale, Tanmay
Babu, Krishna R
author_sort Behera, Geeta
collection PubMed
description Here, we report a case of acute endothelial graft rejection following coronavirus disease 2019 (COVID-19). A 57-year-old woman who underwent therapeutic penetrating keratoplasty for a perforated infectious corneal ulcer in her right eye developed severe acute respiratory syndrome coronavirus 2 infection, which required intensive care and treatment with steroids. Acute endothelial graft rejection was seen at three weeks postoperatively and managed with high-dose corticosteroids. Despite standard therapy, secondary graft failure was observed. Immune dysregulation associated with COVID-19 may be a significant cause of acute endothelial graft rejection among keratoplasty patients with COVID-19.
format Online
Article
Text
id pubmed-8550024
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-85500242021-10-28 Acute Endothelial Graft Rejection Following COVID-19 Infection Behera, Geeta Gokhale, Tanmay Babu, Krishna R Cureus Ophthalmology Here, we report a case of acute endothelial graft rejection following coronavirus disease 2019 (COVID-19). A 57-year-old woman who underwent therapeutic penetrating keratoplasty for a perforated infectious corneal ulcer in her right eye developed severe acute respiratory syndrome coronavirus 2 infection, which required intensive care and treatment with steroids. Acute endothelial graft rejection was seen at three weeks postoperatively and managed with high-dose corticosteroids. Despite standard therapy, secondary graft failure was observed. Immune dysregulation associated with COVID-19 may be a significant cause of acute endothelial graft rejection among keratoplasty patients with COVID-19. Cureus 2021-10-27 /pmc/articles/PMC8550024/ /pubmed/34722015 http://dx.doi.org/10.7759/cureus.19084 Text en Copyright © 2021, Behera et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Ophthalmology
Behera, Geeta
Gokhale, Tanmay
Babu, Krishna R
Acute Endothelial Graft Rejection Following COVID-19 Infection
title Acute Endothelial Graft Rejection Following COVID-19 Infection
title_full Acute Endothelial Graft Rejection Following COVID-19 Infection
title_fullStr Acute Endothelial Graft Rejection Following COVID-19 Infection
title_full_unstemmed Acute Endothelial Graft Rejection Following COVID-19 Infection
title_short Acute Endothelial Graft Rejection Following COVID-19 Infection
title_sort acute endothelial graft rejection following covid-19 infection
topic Ophthalmology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550024/
https://www.ncbi.nlm.nih.gov/pubmed/34722015
http://dx.doi.org/10.7759/cureus.19084
work_keys_str_mv AT beherageeta acuteendothelialgraftrejectionfollowingcovid19infection
AT gokhaletanmay acuteendothelialgraftrejectionfollowingcovid19infection
AT babukrishnar acuteendothelialgraftrejectionfollowingcovid19infection

Ejemplares similares