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Ryanodine receptor leak triggers fiber Ca(2+) redistribution to preserve force and elevate basal metabolism in skeletal muscle

Muscle contraction depends on tightly regulated Ca(2+) release. Aberrant Ca(2+) leak through ryanodine receptor 1 (RyR1) on the sarcoplasmic reticulum (SR) membrane can lead to heatstroke and malignant hyperthermia (MH) susceptibility, as well as severe myopathy. However, the mechanism by which Ca(2...

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Detalles Bibliográficos
Autores principales:	Lamboley, Cedric R., Pearce, Luke, Seng, Crystal, Meizoso-Huesca, Aldo, Singh, Daniel P., Frankish, Barnaby P., Kaura, Vikas, Lo, Harriet P., Ferguson, Charles, Allen, Paul D., Hopkins, Philip M., Parton, Robert G., Murphy, Robyn M., van der Poel, Chris, Barclay, Christopher J., Launikonis, Bradley S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550231/ https://www.ncbi.nlm.nih.gov/pubmed/34705503 http://dx.doi.org/10.1126/sciadv.abi7166

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