An EMT–primary cilium–GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis

The epithelial-mesenchymal transition (EMT) and primary ciliogenesis induce stem cell properties in basal mammary stem cells (MaSCs) to promote mammogenesis, but the underlying mechanisms remain incompletely understood. Here, we show that EMT transcription factors promote ciliogenesis upon entry int...

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Detalles Bibliográficos
Autores principales: Wilson, Molly M., Callens, Céline, Le Gallo, Matthieu, Mironov, Svetlana, Ding, Qiong, Salamagnon, Amandine, Chavarria, Tony E., Viel, Roselyne, Peasah, Abena D., Bhutkar, Arjun, Martin, Sophie, Godey, Florence, Tas, Patrick, Kang, Hong Soon, Juin, Philippe P., Jetten, Anton M., Visvader, Jane E., Weinberg, Robert A., Attanasio, Massimo, Prigent, Claude, Lees, Jacqueline A., Guen, Vincent J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550236/
https://www.ncbi.nlm.nih.gov/pubmed/34705506
http://dx.doi.org/10.1126/sciadv.abf6063

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