An unexpected role for Dicer as a reader of the unacetylated DNA binding domain of p53 in transcriptional regulation

Here, we identified Dicer as a major cellular factor that recognizes the DNA binding domain (DBD) of p53 in a manner dependent on its acetylation status. Upon binding the unacetylated DBD, Dicer is recruited to the promoters of p53 target genes, where it represses p53-mediated transcriptional activa...

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Detalles Bibliográficos
Autores principales: Yang, Xin, Wang, Xingwu, Li, Zhiming, Duan, Shoufu, Li, Huan, Jin, Jian, Zhang, Zhiguo, Gu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550248/
https://www.ncbi.nlm.nih.gov/pubmed/34705508
http://dx.doi.org/10.1126/sciadv.abi6684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550248/
https://www.ncbi.nlm.nih.gov/pubmed/34705508
http://dx.doi.org/10.1126/sciadv.abi6684

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