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Ectopic expression of Irx3 and Irx5 in the paraventricular nucleus of the hypothalamus contributes to defects in Sim1 haploinsufficiency

The paraventricular nucleus of the hypothalamus (PVH) contains a heterogeneous cluster of Sim1-expressing neurons critical for feeding regulation. Sim1 haploinsufficiency results in hyperphagic obesity with disruption of PVH neurons, yet the molecular profiles of PVH neurons and the mechanism underl...

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Detalles Bibliográficos
Autores principales:	Son, Joe Eun, Dou, Zhengchao, Wanggou, Siyi, Chan, Jade, Mo, Rong, Li, Xuejun, Huang, Xi, Kim, Kyoung-Han, Michaud, Jacques L., Hui, Chi-chung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550250/ https://www.ncbi.nlm.nih.gov/pubmed/34705510 http://dx.doi.org/10.1126/sciadv.abh4503

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