Hantaviruses use the endogenous host factor P58(IPK) to combat the PKR antiviral response

Hantavirus nucleocapsid protein (NP) inhibits protein kinase R (PKR) dimerization by an unknown mechanism to counteract its antiviral responses during virus infection. Here we demonstrate that NP exploits an endogenous PKR inhibitor P58(IPK) to inhibit PKR. The activity of P58(IPK) is normally restr...

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Detalles Bibliográficos
Autores principales: Wang, Zekun, Ren, Songyang, Li, Qiming, Royster, Austin D., lin, Lei, Liu, Sichen, Ganaie, Safder S., Qiu, Jianming, Mir, Sheema, Mir, Mohammad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550428/
https://www.ncbi.nlm.nih.gov/pubmed/34653226
http://dx.doi.org/10.1371/journal.ppat.1010007

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