CAR T cell therapy in solid tumors: a short review

Chimeric antigen receptor (CAR) T cell therapy has been established in the treatment of hematological malignancies. However, in solid tumors its efficacy remains limited. The aim of this article is to give an overview of the field of cell therapy itself, to introduce the underlying concepts of CAR T...

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Detalles Bibliográficos
Autores principales: Umut, Öykü, Gottschlich, Adrian, Endres, Stefan, Kobold, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550638/
https://www.ncbi.nlm.nih.gov/pubmed/34777609
http://dx.doi.org/10.1007/s12254-021-00703-7
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author Umut, Öykü
Gottschlich, Adrian
Endres, Stefan
Kobold, Sebastian
author_facet Umut, Öykü
Gottschlich, Adrian
Endres, Stefan
Kobold, Sebastian
author_sort Umut, Öykü
collection PubMed
description Chimeric antigen receptor (CAR) T cell therapy has been established in the treatment of hematological malignancies. However, in solid tumors its efficacy remains limited. The aim of this article is to give an overview of the field of cell therapy itself, to introduce the underlying concepts of CAR T cell-based treatment approaches and to address its limitations in advancing the treatment for solid malignancies.
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spelling pubmed-85506382021-11-10 CAR T cell therapy in solid tumors: a short review Umut, Öykü Gottschlich, Adrian Endres, Stefan Kobold, Sebastian Memo Review Chimeric antigen receptor (CAR) T cell therapy has been established in the treatment of hematological malignancies. However, in solid tumors its efficacy remains limited. The aim of this article is to give an overview of the field of cell therapy itself, to introduce the underlying concepts of CAR T cell-based treatment approaches and to address its limitations in advancing the treatment for solid malignancies. Springer Vienna 2021-04-08 2021 /pmc/articles/PMC8550638/ /pubmed/34777609 http://dx.doi.org/10.1007/s12254-021-00703-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Umut, Öykü
Gottschlich, Adrian
Endres, Stefan
Kobold, Sebastian
CAR T cell therapy in solid tumors: a short review
title CAR T cell therapy in solid tumors: a short review
title_full CAR T cell therapy in solid tumors: a short review
title_fullStr CAR T cell therapy in solid tumors: a short review
title_full_unstemmed CAR T cell therapy in solid tumors: a short review
title_short CAR T cell therapy in solid tumors: a short review
title_sort car t cell therapy in solid tumors: a short review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550638/
https://www.ncbi.nlm.nih.gov/pubmed/34777609
http://dx.doi.org/10.1007/s12254-021-00703-7
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