ISSLS prize in basic science 2021: a novel inducible system to regulate transgene expression of TIMP1

PURPOSE: Inflammatory and oxidative stress upregulates matrix metalloproteinase (MMP) activity, leading to intervertebral disc degeneration (IDD). Gene therapy using human tissue inhibitor of metalloproteinase 1 (hTIMP1) has effectively treated IDD in animal models. However, persistent unregulated t...

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Detalles Bibliográficos
Autores principales: Han, Yingchao, Ouyang, Zhihua, Wawrose, Richard A., Chen, Stephen R., Hallbaum, Maximiliane, Dong, Qing, Dando, Emily, Tang, Ying, Wang, Bing, Lee, Joon Y., Shaw, Jeremy D., Kang, James D., Sowa, Gwendolyn A., Vo, Nam N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550652/
https://www.ncbi.nlm.nih.gov/pubmed/33523281
http://dx.doi.org/10.1007/s00586-021-06728-0

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