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Inflammation, a common mechanism in frailty and COVID‐19, and stem cells as a therapeutic approach

As our life expectancy increases, specific medical conditions appear, and new challenges are met in terms of global health. Frailty has become a medical and scientific concept to define pathologies where inflammation, depressed immune system, cellular senescence, and molecular aging converge. But mo...

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Detalles Bibliográficos
Autores principales: Becerra, José, Duran, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550702/
https://www.ncbi.nlm.nih.gov/pubmed/34164948
http://dx.doi.org/10.1002/sctm.21-0074
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author Becerra, José
Duran, Ivan
author_facet Becerra, José
Duran, Ivan
author_sort Becerra, José
collection PubMed
description As our life expectancy increases, specific medical conditions appear, and new challenges are met in terms of global health. Frailty has become a medical and scientific concept to define pathologies where inflammation, depressed immune system, cellular senescence, and molecular aging converge. But more importantly, frailty is the ultimate cause of death that limits our life span and deteriorates health in an increasing proportion of the world population. The difficulty of tackling this problem is the combination of factors that influence frailty appearance, such as stem cells exhaustion, inflammation, loss of regeneration capability, and impaired immunomodulation. To date, multiple research fields have found mechanisms participating in this health condition, but to make progress, science will need to investigate frailty with an interdisciplinary approach. This article summarizes the current efforts to understand frailty from their processes mediated by inflammation, aging, and stem cells to provide a new perspective that unifies the efforts in producing advanced therapies against medical conditions in the context of frailty. We believe this approach against frailty is particularly relevant to COVID‐19, since people in a state of frailty die more frequently due to the hyperinflammatory process associated with this infection.
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spelling pubmed-85507022021-11-04 Inflammation, a common mechanism in frailty and COVID‐19, and stem cells as a therapeutic approach Becerra, José Duran, Ivan Stem Cells Transl Med Concise Reviews As our life expectancy increases, specific medical conditions appear, and new challenges are met in terms of global health. Frailty has become a medical and scientific concept to define pathologies where inflammation, depressed immune system, cellular senescence, and molecular aging converge. But more importantly, frailty is the ultimate cause of death that limits our life span and deteriorates health in an increasing proportion of the world population. The difficulty of tackling this problem is the combination of factors that influence frailty appearance, such as stem cells exhaustion, inflammation, loss of regeneration capability, and impaired immunomodulation. To date, multiple research fields have found mechanisms participating in this health condition, but to make progress, science will need to investigate frailty with an interdisciplinary approach. This article summarizes the current efforts to understand frailty from their processes mediated by inflammation, aging, and stem cells to provide a new perspective that unifies the efforts in producing advanced therapies against medical conditions in the context of frailty. We believe this approach against frailty is particularly relevant to COVID‐19, since people in a state of frailty die more frequently due to the hyperinflammatory process associated with this infection. John Wiley & Sons, Inc. 2021-08-03 /pmc/articles/PMC8550702/ /pubmed/34164948 http://dx.doi.org/10.1002/sctm.21-0074 Text en © 2021 The Authors. stem cells translational medicine published by Wiley Periodicals LLC on behalf of AlphaMed Press. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Concise Reviews
Becerra, José
Duran, Ivan
Inflammation, a common mechanism in frailty and COVID‐19, and stem cells as a therapeutic approach
title Inflammation, a common mechanism in frailty and COVID‐19, and stem cells as a therapeutic approach
title_full Inflammation, a common mechanism in frailty and COVID‐19, and stem cells as a therapeutic approach
title_fullStr Inflammation, a common mechanism in frailty and COVID‐19, and stem cells as a therapeutic approach
title_full_unstemmed Inflammation, a common mechanism in frailty and COVID‐19, and stem cells as a therapeutic approach
title_short Inflammation, a common mechanism in frailty and COVID‐19, and stem cells as a therapeutic approach
title_sort inflammation, a common mechanism in frailty and covid‐19, and stem cells as a therapeutic approach
topic Concise Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550702/
https://www.ncbi.nlm.nih.gov/pubmed/34164948
http://dx.doi.org/10.1002/sctm.21-0074
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