Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

Activating LRRK2 mutations cause Parkinson’s disease, and pathogenic LRRK2 kinase interferes with ciliogenesis. Previously, we showed that cholinergic interneurons of the dorsal striatum lose their cilia in R1441C LRRK2 mutant mice (Dhekne et al., 2018). Here, we show that cilia loss is seen as earl...

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Detalles Bibliográficos
Autores principales: Khan, Shahzad S, Sobu, Yuriko, Dhekne, Herschel S, Tonelli, Francesca, Berndsen, Kerryn, Alessi, Dario R, Pfeffer, Suzanne R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550758/
https://www.ncbi.nlm.nih.gov/pubmed/34658337
http://dx.doi.org/10.7554/eLife.67900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550758/
https://www.ncbi.nlm.nih.gov/pubmed/34658337
http://dx.doi.org/10.7554/eLife.67900

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