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Epigenetic interaction of microbes with their mammalian hosts

The interaction of microbiota with its host has the ability to alter the cellular functions of both, through several mechanisms. Recent work, from many laboratories including our own, has shown that epigenetic mechanisms play an important role in the alteration of these cellular functions. Epigeneti...

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Autores principales: Rajeev, Ramisetti, Dwivedi, Ambey Prasad, Sinha, Anunay, Agarwaal, Viplove, Dev, Rachana Roshan, Kar, Anjana, Khosla, Sanjeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550911/
https://www.ncbi.nlm.nih.gov/pubmed/34728591
http://dx.doi.org/10.1007/s12038-021-00215-w
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author Rajeev, Ramisetti
Dwivedi, Ambey Prasad
Sinha, Anunay
Agarwaal, Viplove
Dev, Rachana Roshan
Kar, Anjana
Khosla, Sanjeev
author_facet Rajeev, Ramisetti
Dwivedi, Ambey Prasad
Sinha, Anunay
Agarwaal, Viplove
Dev, Rachana Roshan
Kar, Anjana
Khosla, Sanjeev
author_sort Rajeev, Ramisetti
collection PubMed
description The interaction of microbiota with its host has the ability to alter the cellular functions of both, through several mechanisms. Recent work, from many laboratories including our own, has shown that epigenetic mechanisms play an important role in the alteration of these cellular functions. Epigenetics broadly refers to change in the phenotype without a corresponding change in the DNA sequence. This change is usually brought by epigenetic modifications of the DNA itself, the histone proteins associated with the DNA in the chromatin, non-coding RNA or the modifications of the transcribed RNA. These modifications, also known as epigenetic code, do not change the DNA sequence but alter the expression level of specific genes. Microorganisms seem to have learned how to modify the host epigenetic code and modulate the host transcriptome in their favour. In this review, we explore the literature that describes the epigenetic interaction of bacteria, fungi and viruses, with their mammalian hosts.
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spelling pubmed-85509112021-10-28 Epigenetic interaction of microbes with their mammalian hosts Rajeev, Ramisetti Dwivedi, Ambey Prasad Sinha, Anunay Agarwaal, Viplove Dev, Rachana Roshan Kar, Anjana Khosla, Sanjeev J Biosci Review The interaction of microbiota with its host has the ability to alter the cellular functions of both, through several mechanisms. Recent work, from many laboratories including our own, has shown that epigenetic mechanisms play an important role in the alteration of these cellular functions. Epigenetics broadly refers to change in the phenotype without a corresponding change in the DNA sequence. This change is usually brought by epigenetic modifications of the DNA itself, the histone proteins associated with the DNA in the chromatin, non-coding RNA or the modifications of the transcribed RNA. These modifications, also known as epigenetic code, do not change the DNA sequence but alter the expression level of specific genes. Microorganisms seem to have learned how to modify the host epigenetic code and modulate the host transcriptome in their favour. In this review, we explore the literature that describes the epigenetic interaction of bacteria, fungi and viruses, with their mammalian hosts. Springer India 2021-10-28 2021 /pmc/articles/PMC8550911/ /pubmed/34728591 http://dx.doi.org/10.1007/s12038-021-00215-w Text en © Indian Academy of Sciences 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Rajeev, Ramisetti
Dwivedi, Ambey Prasad
Sinha, Anunay
Agarwaal, Viplove
Dev, Rachana Roshan
Kar, Anjana
Khosla, Sanjeev
Epigenetic interaction of microbes with their mammalian hosts
title Epigenetic interaction of microbes with their mammalian hosts
title_full Epigenetic interaction of microbes with their mammalian hosts
title_fullStr Epigenetic interaction of microbes with their mammalian hosts
title_full_unstemmed Epigenetic interaction of microbes with their mammalian hosts
title_short Epigenetic interaction of microbes with their mammalian hosts
title_sort epigenetic interaction of microbes with their mammalian hosts
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550911/
https://www.ncbi.nlm.nih.gov/pubmed/34728591
http://dx.doi.org/10.1007/s12038-021-00215-w
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