HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions

Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separate...

Descripción completa

Detalles Bibliográficos
Autores principales: Bruford, Elspeth A., Antonescu, Cristina R., Carroll, Andrew J., Chinnaiyan, Arul, Cree, Ian A., Cross, Nicholas C. P., Dalgleish, Raymond, Gale, Robert Peter, Harrison, Christine J., Hastings, Rosalind J., Huret, Jean-Loup, Johansson, Bertil, Le Beau, Michelle, Mecucci, Cristina, Mertens, Fredrik, Verhaak, Roel, Mitelman, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Consensus Statement
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550944/
https://www.ncbi.nlm.nih.gov/pubmed/34615987
http://dx.doi.org/10.1038/s41375-021-01436-6
_version_ 1784591063464280064
author Bruford, Elspeth A.
Antonescu, Cristina R.
Carroll, Andrew J.
Chinnaiyan, Arul
Cree, Ian A.
Cross, Nicholas C. P.
Dalgleish, Raymond
Gale, Robert Peter
Harrison, Christine J.
Hastings, Rosalind J.
Huret, Jean-Loup
Johansson, Bertil
Le Beau, Michelle
Mecucci, Cristina
Mertens, Fredrik
Verhaak, Roel
Mitelman, Felix
author_facet Bruford, Elspeth A.
Antonescu, Cristina R.
Carroll, Andrew J.
Chinnaiyan, Arul
Cree, Ian A.
Cross, Nicholas C. P.
Dalgleish, Raymond
Gale, Robert Peter
Harrison, Christine J.
Hastings, Rosalind J.
Huret, Jean-Loup
Johansson, Bertil
Le Beau, Michelle
Mecucci, Cristina
Mertens, Fredrik
Verhaak, Roel
Mitelman, Felix
author_sort Bruford, Elspeth A.
collection PubMed
description Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortcomings. HGNC has worked with the scientific community to determine a new, instantly recognizable and unique separator—a double colon (::)—to be used in the description of fusion genes, and advocates its usage in all databases and articles describing gene fusions.
format Online
Article
Text
id pubmed-8550944
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-85509442021-11-10 HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions Bruford, Elspeth A. Antonescu, Cristina R. Carroll, Andrew J. Chinnaiyan, Arul Cree, Ian A. Cross, Nicholas C. P. Dalgleish, Raymond Gale, Robert Peter Harrison, Christine J. Hastings, Rosalind J. Huret, Jean-Loup Johansson, Bertil Le Beau, Michelle Mecucci, Cristina Mertens, Fredrik Verhaak, Roel Mitelman, Felix Leukemia Consensus Statement Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortcomings. HGNC has worked with the scientific community to determine a new, instantly recognizable and unique separator—a double colon (::)—to be used in the description of fusion genes, and advocates its usage in all databases and articles describing gene fusions. Nature Publishing Group UK 2021-10-06 2021 /pmc/articles/PMC8550944/ /pubmed/34615987 http://dx.doi.org/10.1038/s41375-021-01436-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Consensus Statement
Bruford, Elspeth A.
Antonescu, Cristina R.
Carroll, Andrew J.
Chinnaiyan, Arul
Cree, Ian A.
Cross, Nicholas C. P.
Dalgleish, Raymond
Gale, Robert Peter
Harrison, Christine J.
Hastings, Rosalind J.
Huret, Jean-Loup
Johansson, Bertil
Le Beau, Michelle
Mecucci, Cristina
Mertens, Fredrik
Verhaak, Roel
Mitelman, Felix
HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions
title HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions
title_full HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions
title_fullStr HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions
title_full_unstemmed HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions
title_short HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions
title_sort hugo gene nomenclature committee (hgnc) recommendations for the designation of gene fusions
topic Consensus Statement
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550944/
https://www.ncbi.nlm.nih.gov/pubmed/34615987
http://dx.doi.org/10.1038/s41375-021-01436-6
work_keys_str_mv AT brufordelspetha hugogenenomenclaturecommitteehgncrecommendationsforthedesignationofgenefusions
AT antonescucristinar hugogenenomenclaturecommitteehgncrecommendationsforthedesignationofgenefusions
AT carrollandrewj hugogenenomenclaturecommitteehgncrecommendationsforthedesignationofgenefusions
AT chinnaiyanarul hugogenenomenclaturecommitteehgncrecommendationsforthedesignationofgenefusions
AT creeiana hugogenenomenclaturecommitteehgncrecommendationsforthedesignationofgenefusions
AT crossnicholascp hugogenenomenclaturecommitteehgncrecommendationsforthedesignationofgenefusions
AT dalgleishraymond hugogenenomenclaturecommitteehgncrecommendationsforthedesignationofgenefusions
AT galerobertpeter hugogenenomenclaturecommitteehgncrecommendationsforthedesignationofgenefusions
AT harrisonchristinej hugogenenomenclaturecommitteehgncrecommendationsforthedesignationofgenefusions
AT hastingsrosalindj hugogenenomenclaturecommitteehgncrecommendationsforthedesignationofgenefusions
AT huretjeanloup hugogenenomenclaturecommitteehgncrecommendationsforthedesignationofgenefusions
AT johanssonbertil hugogenenomenclaturecommitteehgncrecommendationsforthedesignationofgenefusions
AT lebeaumichelle hugogenenomenclaturecommitteehgncrecommendationsforthedesignationofgenefusions
AT mecuccicristina hugogenenomenclaturecommitteehgncrecommendationsforthedesignationofgenefusions
AT mertensfredrik hugogenenomenclaturecommitteehgncrecommendationsforthedesignationofgenefusions
AT verhaakroel hugogenenomenclaturecommitteehgncrecommendationsforthedesignationofgenefusions
AT mitelmanfelix hugogenenomenclaturecommitteehgncrecommendationsforthedesignationofgenefusions

Ejemplares similares