Cargando…

A novel device for treatment of osteonecrosis of femoral head: Feasibility and preliminary efficacy of animal study

BACKGROUND: Interruption of blood supply will lead to necrosis of body tissues, such as osteonecrosis of femoral head (ONFH). Vascularization has always been regarded as one of the biggest challenges in tissue engineering. In the current study, a novel device was proposed to reconstruct blood supply...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Bo, Yu, Lingjia, Huang, Zhenfei, Liang, Yongxin, Li, Guangping, Zhao, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550985/
https://www.ncbi.nlm.nih.gov/pubmed/34760621
http://dx.doi.org/10.1016/j.jot.2021.09.002
_version_ 1784591071504760832
author Li, Bo
Yu, Lingjia
Huang, Zhenfei
Liang, Yongxin
Li, Guangping
Zhao, Yu
author_facet Li, Bo
Yu, Lingjia
Huang, Zhenfei
Liang, Yongxin
Li, Guangping
Zhao, Yu
author_sort Li, Bo
collection PubMed
description BACKGROUND: Interruption of blood supply will lead to necrosis of body tissues, such as osteonecrosis of femoral head (ONFH). Vascularization has always been regarded as one of the biggest challenges in tissue engineering. In the current study, a novel device was proposed to reconstruct blood supply of necrotic femoral head. METHODS: Cryo-insult with liquid nitrogen method was adopted to establish the ONFH model. In experimental group, a novel scaffold carrying vascular bundle was implanted into the necrotic femoral head after decompression and the transplanted vascular bundles were anastomosed with the existing blood vessels around the hip. In control group, a traditional porous scaffold was inserted alone without vessels. Feasibility of this strategy was verified by animal experiments. Micro-CT analysis and histological evaluation were performed to investigate its preliminary efficacy. RESULTS: Feasibility of this innovative treatment strategy had been successfully verified in animal experiments. In the area of necrosis repair, more bone tissue grew into the scaffold in experimental group than the control group evaluated by Micro-CT (three months: 29.66% VS 20.35%, P<0.05; six months: 30.47% VS 25.10%, P<0.05) and histological analysis (24.71% VS 16.45%, P<0.05 ​at three months; 31.01% VS 20.60%, P<0.05 ​at six months). Implanted vascular bundles had the potential to branch out many branches in the osteonecrosis repair area to facilitate blood supply reconstruction and bone repair. CONCLUSIONS: This study proposed a novel device with clinical application prospects in the treatment of ONFH. It has the potential to provide new possibilities for rebuilding the blood supply of femoral head and repairing osteonecrosis. TRANSLATIONAL POTENTIAL STATEMENT: The novel device proposed in this study has the potential to be applied to the treatment of early femoral head necrosis.
format Online
Article
Text
id pubmed-8550985
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Chinese Speaking Orthopaedic Society
record_format MEDLINE/PubMed
spelling pubmed-85509852021-11-09 A novel device for treatment of osteonecrosis of femoral head: Feasibility and preliminary efficacy of animal study Li, Bo Yu, Lingjia Huang, Zhenfei Liang, Yongxin Li, Guangping Zhao, Yu J Orthop Translat Original Article BACKGROUND: Interruption of blood supply will lead to necrosis of body tissues, such as osteonecrosis of femoral head (ONFH). Vascularization has always been regarded as one of the biggest challenges in tissue engineering. In the current study, a novel device was proposed to reconstruct blood supply of necrotic femoral head. METHODS: Cryo-insult with liquid nitrogen method was adopted to establish the ONFH model. In experimental group, a novel scaffold carrying vascular bundle was implanted into the necrotic femoral head after decompression and the transplanted vascular bundles were anastomosed with the existing blood vessels around the hip. In control group, a traditional porous scaffold was inserted alone without vessels. Feasibility of this strategy was verified by animal experiments. Micro-CT analysis and histological evaluation were performed to investigate its preliminary efficacy. RESULTS: Feasibility of this innovative treatment strategy had been successfully verified in animal experiments. In the area of necrosis repair, more bone tissue grew into the scaffold in experimental group than the control group evaluated by Micro-CT (three months: 29.66% VS 20.35%, P<0.05; six months: 30.47% VS 25.10%, P<0.05) and histological analysis (24.71% VS 16.45%, P<0.05 ​at three months; 31.01% VS 20.60%, P<0.05 ​at six months). Implanted vascular bundles had the potential to branch out many branches in the osteonecrosis repair area to facilitate blood supply reconstruction and bone repair. CONCLUSIONS: This study proposed a novel device with clinical application prospects in the treatment of ONFH. It has the potential to provide new possibilities for rebuilding the blood supply of femoral head and repairing osteonecrosis. TRANSLATIONAL POTENTIAL STATEMENT: The novel device proposed in this study has the potential to be applied to the treatment of early femoral head necrosis. Chinese Speaking Orthopaedic Society 2021-10-21 /pmc/articles/PMC8550985/ /pubmed/34760621 http://dx.doi.org/10.1016/j.jot.2021.09.002 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Li, Bo
Yu, Lingjia
Huang, Zhenfei
Liang, Yongxin
Li, Guangping
Zhao, Yu
A novel device for treatment of osteonecrosis of femoral head: Feasibility and preliminary efficacy of animal study
title A novel device for treatment of osteonecrosis of femoral head: Feasibility and preliminary efficacy of animal study
title_full A novel device for treatment of osteonecrosis of femoral head: Feasibility and preliminary efficacy of animal study
title_fullStr A novel device for treatment of osteonecrosis of femoral head: Feasibility and preliminary efficacy of animal study
title_full_unstemmed A novel device for treatment of osteonecrosis of femoral head: Feasibility and preliminary efficacy of animal study
title_short A novel device for treatment of osteonecrosis of femoral head: Feasibility and preliminary efficacy of animal study
title_sort novel device for treatment of osteonecrosis of femoral head: feasibility and preliminary efficacy of animal study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550985/
https://www.ncbi.nlm.nih.gov/pubmed/34760621
http://dx.doi.org/10.1016/j.jot.2021.09.002
work_keys_str_mv AT libo anoveldevicefortreatmentofosteonecrosisoffemoralheadfeasibilityandpreliminaryefficacyofanimalstudy
AT yulingjia anoveldevicefortreatmentofosteonecrosisoffemoralheadfeasibilityandpreliminaryefficacyofanimalstudy
AT huangzhenfei anoveldevicefortreatmentofosteonecrosisoffemoralheadfeasibilityandpreliminaryefficacyofanimalstudy
AT liangyongxin anoveldevicefortreatmentofosteonecrosisoffemoralheadfeasibilityandpreliminaryefficacyofanimalstudy
AT liguangping anoveldevicefortreatmentofosteonecrosisoffemoralheadfeasibilityandpreliminaryefficacyofanimalstudy
AT zhaoyu anoveldevicefortreatmentofosteonecrosisoffemoralheadfeasibilityandpreliminaryefficacyofanimalstudy
AT libo noveldevicefortreatmentofosteonecrosisoffemoralheadfeasibilityandpreliminaryefficacyofanimalstudy
AT yulingjia noveldevicefortreatmentofosteonecrosisoffemoralheadfeasibilityandpreliminaryefficacyofanimalstudy
AT huangzhenfei noveldevicefortreatmentofosteonecrosisoffemoralheadfeasibilityandpreliminaryefficacyofanimalstudy
AT liangyongxin noveldevicefortreatmentofosteonecrosisoffemoralheadfeasibilityandpreliminaryefficacyofanimalstudy
AT liguangping noveldevicefortreatmentofosteonecrosisoffemoralheadfeasibilityandpreliminaryefficacyofanimalstudy
AT zhaoyu noveldevicefortreatmentofosteonecrosisoffemoralheadfeasibilityandpreliminaryefficacyofanimalstudy