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Reconstruction of evolving gene variants and fitness from short sequencing reads
Directed evolution can generate proteins with tailor-made activities. However, full-length genotypes, their frequencies, and fitnesses are difficult to measure for evolving gene-length biomolecules using most high-throughput DNA sequencing methods as short read lengths can lose mutation linkages in...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551035/ https://www.ncbi.nlm.nih.gov/pubmed/34635842 http://dx.doi.org/10.1038/s41589-021-00876-6 |