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Conditions for maintenance of hepatocyte differentiation and function in 3D cultures

Spheroid cultures of primary human hepatocytes (PHH) are used in studies of hepatic drug metabolism and toxicity. The cultures are maintained under different conditions, with possible confounding results. We performed an in-depth analysis of the influence of various culture conditions to find the op...

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Detalles Bibliográficos
Autores principales:	Handin, Niklas, Mickols, Evgeniya, Ölander, Magnus, Rudfeldt, Jakob, Blom, Kristin, Nyberg, Frida, Senkowski, Wojciech, Urdzik, Jozef, Maturi, Varun, Fryknäs, Mårten, Artursson, Per
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551077/ https://www.ncbi.nlm.nih.gov/pubmed/34746700 http://dx.doi.org/10.1016/j.isci.2021.103235

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